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Assay Detail

CHEMBL702378

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Functional
Inhibitory activity evaluated against human jurkat cell line in cellular assay
ChEMBL ↗
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Expert

Target

Jurkat (CHEMBL397) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
Linton SD, Aja T, Allegrini PR, Deckwerth TL, Diaz JL, Hengerer B, Herrmann J, Jahangiri KG, Kallen J, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo S, Rovelli G, Sauter A, Sayers RO, Schmitz A, Smidt R, Ternansky RJ, Tomaselli KJ, Ullman BR, Wiessner C, Wu JC.
Bioorg Med Chem Lett (2004) 14 : 2685 -2691
PubMed 15109679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 52 6.91 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL92317 — — 1 9.15
CHEMBL90185 — — 1 8.77
CHEMBL93960 — — 1 8.66
CHEMBL91423 — — 1 8.37
CHEMBL430839 — — 1 8.28
CHEMBL88540 — — 1 8.21
CHEMBL328066 — — 1 8.05
CHEMBL88719 — — 1 8.00
CHEMBL91406 — — 1 8.00
CHEMBL90293 — — 1 7.89
CHEMBL92848 — — 1 7.80
CHEMBL316102 — — 1 7.77
CHEMBL314733 — — 1 7.72
CHEMBL313158 — — 1 7.52
CHEMBL327211 — — 1 7.40
CHEMBL94069 — — 1 7.39
CHEMBL91279 — — 1 7.22
CHEMBL93177 — — 1 7.16
CHEMBL315954 — — 1 7.11
CHEMBL314096 — — 1 7.09
CHEMBL90516 — — 1 7.01
CHEMBL88358 — — 1 6.96
CHEMBL328988 — — 1 6.96
CHEMBL315868 — — 1 6.87
CHEMBL1160622 — — 1 6.85
CHEMBL91032 — — 1 6.82
CHEMBL1160621 — — 1 6.77
CHEMBL88786 — — 1 6.76
CHEMBL92029 — — 1 6.72
CHEMBL91442 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL92317 — IC50 = 0.7 nM 9.15
CHEMBL90185 — IC50 = 1.7 nM 8.77
CHEMBL93960 — IC50 = 2.2 nM 8.66
CHEMBL91423 — IC50 = 4.3 nM 8.37
CHEMBL430839 — IC50 = 5.2 nM 8.28
CHEMBL88540 — IC50 = 6.1 nM 8.21
CHEMBL328066 — IC50 = 9.0 nM 8.05
CHEMBL88719 — IC50 = 10.0 nM 8.00
CHEMBL91406 — IC50 = 10.0 nM 8.00
CHEMBL90293 — IC50 = 13.0 nM 7.89
CHEMBL92848 — IC50 = 16.0 nM 7.80
CHEMBL316102 — IC50 = 17.0 nM 7.77
CHEMBL314733 — IC50 = 19.0 nM 7.72
CHEMBL313158 — IC50 = 30.0 nM 7.52
CHEMBL327211 — IC50 = 40.0 nM 7.40
CHEMBL94069 — IC50 = 41.0 nM 7.39
CHEMBL91279 — IC50 = 60.0 nM 7.22
CHEMBL93177 — IC50 = 70.0 nM 7.16
CHEMBL315954 — IC50 = 77.1 nM 7.11
CHEMBL314096 — IC50 = 81.0 nM 7.09
CHEMBL90516 — IC50 = 97.0 nM 7.01
CHEMBL88358 — IC50 = 110.0 nM 6.96
CHEMBL328988 — IC50 = 110.0 nM 6.96
CHEMBL315868 — IC50 = 136.0 nM 6.87
CHEMBL1160622 — IC50 = 140.0 nM 6.85
CHEMBL91032 — IC50 = 150.0 nM 6.82
CHEMBL1160621 — IC50 = 170.0 nM 6.77
CHEMBL88786 — IC50 = 175.0 nM 6.76
CHEMBL92029 — IC50 = 190.0 nM 6.72
CHEMBL91442 — IC50 = 200.0 nM 6.70
CHEMBL316289 — IC50 = 220.0 nM 6.66
CHEMBL316101 — IC50 = 270.0 nM 6.57
CHEMBL90589 — IC50 = 310.0 nM 6.51
CHEMBL327821 — IC50 = 356.0 nM 6.45
CHEMBL330534 — IC50 = 370.0 nM 6.43
CHEMBL91825 — IC50 = 390.0 nM 6.41
CHEMBL327207 — IC50 = 430.0 nM 6.37
CHEMBL330110 — IC50 = 520.0 nM 6.28
CHEMBL90061 — IC50 = 535.0 nM 6.27
CHEMBL327464 — IC50 = 660.0 nM 6.18
CHEMBL327458 — IC50 = 1150.0 nM 5.94
CHEMBL91307 — IC50 = 1300.0 nM 5.89
CHEMBL88467 — IC50 = 1280.0 nM 5.89
CHEMBL90648 — IC50 = 1550.0 nM 5.81
CHEMBL327683 — IC50 = 1760.0 nM 5.75
CHEMBL92494 — IC50 = 2350.0 nM 5.63
CHEMBL414216 — IC50 = 2500.0 nM 5.60
CHEMBL316450 — IC50 = 4700.0 nM 5.33
CHEMBL1160598 — IC50 = 15800.0 nM 4.80
CHEMBL93053 — IC50 = 30800.0 nM 4.51