Assay Detail
Functional
CHEMBL704796
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In vitro inhibitory activity against Jurkat cell proliferation
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.59 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118645 | — | — | 1 | 4.97 |
| CHEMBL120640 | — | — | 1 | 4.91 |
| CHEMBL332480 | — | — | 1 | 4.79 |
| CHEMBL118395 | — | — | 1 | 4.79 |
| CHEMBL418870 | — | — | 1 | 4.75 |
| CHEMBL118168 | — | — | 1 | 4.51 |
| CHEMBL118489 | — | — | 1 | 4.50 |
| CHEMBL334117 | — | — | 1 | 4.41 |
| CHEMBL432427 | — | — | 1 | 4.39 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 4.38 |
| CHEMBL116946 | — | — | 1 | 4.37 |
| CHEMBL118499 | — | — | 1 | 4.33 |
| CHEMBL118468 | — | — | 1 | - |
| CHEMBL118586 | — | — | 1 | - |
| CHEMBL334317 | — | — | 1 | - |
| CHEMBL119193 | — | — | 1 | - |
| CHEMBL116206 | — | — | 1 | - |
| CHEMBL119697 | — | — | 1 | - |
| CHEMBL119780 | — | — | 1 | - |
| CHEMBL331399 | — | — | 1 | - |
| CHEMBL119801 | — | — | 1 | - |
| CHEMBL333404 | — | — | 1 | - |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | - |
| CHEMBL333344 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118645 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL120640 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL332480 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL118395 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL418870 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL118168 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL118489 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL334117 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL432427 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL116946 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL118499 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL118468 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118586 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL334317 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119193 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL116206 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119697 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119780 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL331399 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119801 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL333404 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL160 | CYCLOSPORINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL333344 | — | IC50 | > | 50000.0 | nM | - |