Assay Detail
Binding
CHEMBL706791
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Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The discovery of a new structural class of potent orally active leukotriene D4 antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.00 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275357 | — | — | 1 | 9.70 |
| CHEMBL15292 | — | — | 1 | 9.40 |
| CHEMBL15370 | — | — | 1 | 9.40 |
| CHEMBL279630 | — | — | 1 | 9.30 |
| CHEMBL15035 | — | — | 1 | 9.30 |
| CHEMBL274049 | — | — | 1 | 9.25 |
| CHEMBL15344 | — | — | 1 | 9.22 |
| CHEMBL278210 | — | — | 1 | 9.10 |
| CHEMBL429975 | — | — | 1 | 8.85 |
| CHEMBL15306 | — | — | 1 | 8.70 |
| CHEMBL280260 | — | — | 1 | 8.70 |
| CHEMBL277533 | — | — | 1 | 8.30 |
| CHEMBL274913 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275357 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL15292 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL15370 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL279630 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL15035 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL274049 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL15344 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL278210 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL429975 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL15306 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL280260 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL277533 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL274913 | — | IC50 | = | 17.0 | nM | 7.77 |