Assay Detail
Binding
CHEMBL706929
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Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 9.22 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330649 | — | — | 1 | 9.70 |
| CHEMBL99775 | — | — | 1 | 9.52 |
| CHEMBL95234 | — | — | 1 | 9.52 |
| CHEMBL96986 | — | — | 1 | 9.48 |
| CHEMBL319802 | — | — | 1 | 9.37 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 9.36 |
| CHEMBL97576 | — | — | 1 | 9.36 |
| CHEMBL787 | MONTELUKAST | 4.0 | 1 | 9.30 |
| CHEMBL95362 | — | — | 1 | 9.24 |
| CHEMBL95317 | — | — | 1 | 9.22 |
| CHEMBL316688 | — | — | 1 | 9.17 |
| CHEMBL98676 | — | — | 1 | 9.10 |
| CHEMBL89768 | — | — | 1 | 8.82 |
| CHEMBL327942 | — | — | 1 | 8.64 |
| CHEMBL89340 | — | — | 1 | 8.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330649 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL99775 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL95234 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL96986 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL319802 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL97576 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL787 | MONTELUKAST | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL95362 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL95317 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL316688 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL98676 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL89768 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL327942 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL89340 | — | IC50 | = | 3.1 | nM | 8.51 |