Assay Detail
Binding
CHEMBL706933
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Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The discovery of a new structural class of potent orally active leukotriene D4 antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.73 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14819 | — | — | 1 | 9.44 |
| CHEMBL15232 | — | — | 1 | 9.40 |
| CHEMBL280310 | — | — | 1 | 9.35 |
| CHEMBL15120 | — | — | 1 | 9.33 |
| CHEMBL15132 | — | — | 1 | 9.28 |
| CHEMBL278411 | — | — | 1 | 9.22 |
| CHEMBL15161 | L-695499 | — | 1 | 9.05 |
| CHEMBL15513 | — | — | 1 | 9.02 |
| CHEMBL279773 | — | — | 1 | 9.02 |
| CHEMBL416161 | — | — | 1 | 9.00 |
| CHEMBL15500 | — | — | 1 | 8.89 |
| CHEMBL430147 | — | — | 1 | 8.72 |
| CHEMBL15177 | MK-571 | — | 2 | 8.52 |
| CHEMBL276584 | — | — | 1 | 8.44 |
| CHEMBL15419 | — | — | 1 | 8.20 |
| CHEMBL15481 | — | — | 1 | 8.19 |
| CHEMBL15485 | — | — | 1 | 8.07 |
| CHEMBL277332 | — | — | 1 | 7.85 |
| CHEMBL15491 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14819 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL15232 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL280310 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL15120 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL15132 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL278411 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL15161 | L-695499 | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL15513 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL279773 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL416161 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL15500 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL430147 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL15177 | MK-571 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL276584 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL15177 | MK-571 | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL15419 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL15481 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL15485 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL277332 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL15491 | — | IC50 | = | 75.0 | nM | 7.12 |