Assay Detail
ADMET
CHEMBL707345
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Cytotoxic activity against rat L6 cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Bisguanidine, bis(2-aminoimidazoline), and polyamine derivatives as potent and selective chemotherapeutic agents against Trypanosoma brucei rhodesiense. Synthesis and in vitro evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.08 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73627 | — | — | 1 | 6.20 |
| CHEMBL77633 | — | — | 1 | 5.55 |
| CHEMBL77647 | — | — | 1 | 5.11 |
| CHEMBL539628 | — | — | 1 | 4.93 |
| CHEMBL307260 | — | — | 1 | 4.61 |
| CHEMBL77852 | — | — | 1 | 4.05 |
| CHEMBL75538 | — | — | 1 | - |
| CHEMBL75414 | — | — | 1 | - |
| CHEMBL77670 | — | — | 1 | - |
| CHEMBL76505 | — | — | 1 | - |
| CHEMBL242759 | — | — | 1 | - |
| CHEMBL78033 | — | — | 1 | - |
| CHEMBL307601 | — | — | 1 | - |
| CHEMBL74921 | — | — | 1 | - |
| CHEMBL423676 | — | — | 1 | - |
| CHEMBL74474 | DODINE | — | 1 | - |
| CHEMBL77810 | — | — | 1 | - |
| CHEMBL309002 | — | — | 1 | - |
| CHEMBL305943 | — | — | 1 | - |
| CHEMBL77596 | — | — | 1 | - |
| CHEMBL308767 | — | — | 1 | - |
| CHEMBL76504 | — | — | 1 | - |
| CHEMBL73758 | — | — | 1 | - |
| CHEMBL267337 | — | — | 1 | - |
| CHEMBL242102 | — | — | 1 | - |
| CHEMBL310704 | — | — | 1 | - |
| CHEMBL306291 | — | — | 1 | - |
| CHEMBL75214 | — | — | 1 | - |
| CHEMBL431961 | — | — | 1 | - |
| CHEMBL75849 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73627 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL77633 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL77647 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL539628 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL307260 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL77852 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL242759 | — | IC50 | 650.0 | nM | - | |
| CHEMBL75847 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL78033 | — | IC50 | = | 104000.0 | nM | - |
| CHEMBL307601 | — | IC50 | 4200.0 | nM | - | |
| CHEMBL74921 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL423676 | — | IC50 | > | 222000.0 | nM | - |
| CHEMBL74474 | DODINE | IC50 | 19600.0 | nM | - | |
| CHEMBL77810 | — | IC50 | > | 199000.0 | nM | - |
| CHEMBL309002 | — | IC50 | 3700.0 | nM | - | |
| CHEMBL75414 | — | IC50 | 9800.0 | nM | - | |
| CHEMBL74371 | — | IC50 | 113000.0 | nM | - | |
| CHEMBL73634 | — | IC50 | > | 276000.0 | nM | - |
| CHEMBL75389 | — | IC50 | 63600.0 | nM | - | |
| CHEMBL74196 | — | IC50 | 4604000.0 | nM | - | |
| CHEMBL15901 | BENZIDINE | IC50 | > | 217000.0 | nM | - |
| CHEMBL76505 | — | IC50 | 16000.0 | nM | - | |
| CHEMBL77670 | — | IC50 | 56400.0 | nM | - | |
| CHEMBL75538 | — | IC50 | > | 244000.0 | nM | - |
| CHEMBL305943 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL77596 | — | IC50 | 214000.0 | nM | - | |
| CHEMBL308767 | — | IC50 | 2700.0 | nM | - | |
| CHEMBL76504 | — | IC50 | 2350.0 | nM | - | |
| CHEMBL73758 | — | IC50 | > | 214000.0 | nM | - |
| CHEMBL267337 | — | IC50 | > | 175000.0 | nM | - |
| CHEMBL242102 | — | IC50 | 212000.0 | nM | - | |
| CHEMBL310704 | — | IC50 | > | 83000.0 | nM | - |
| CHEMBL306291 | — | IC50 | > | 265000.0 | nM | - |
| CHEMBL75214 | — | IC50 | > | 302000.0 | nM | - |
| CHEMBL431961 | — | IC50 | > | 175000.0 | nM | - |
| CHEMBL75849 | — | IC50 | > | 191000.0 | nM | - |