Assay Detail
Binding
CHEMBL709254
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Lutropin-choriogonadotropic hormone receptor (CHEMBL2456) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Stabilization of the N-terminal residues of luteinizing hormone-releasing hormone agonists and the effect on pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.53 | 10.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407606 | — | — | 1 | 10.61 |
| CHEMBL407123 | — | — | 1 | 10.37 |
| CHEMBL405737 | — | — | 1 | 10.11 |
| CHEMBL385042 | — | — | 1 | 10.03 |
| CHEMBL415571 | — | — | 1 | 9.81 |
| CHEMBL429240 | — | — | 1 | 9.68 |
| CHEMBL437798 | — | — | 1 | 9.42 |
| CHEMBL217405 | — | — | 1 | 8.66 |
| CHEMBL274682 | — | — | 1 | 8.59 |
| CHEMBL414071 | — | — | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407606 | — | Ki | = | 0.02455 | nM | 10.61 |
| CHEMBL407123 | — | Ki | = | 0.04266 | nM | 10.37 |
| CHEMBL405737 | — | Ki | = | 0.07762 | nM | 10.11 |
| CHEMBL385042 | — | Ki | = | 0.09333 | nM | 10.03 |
| CHEMBL415571 | — | Ki | = | 0.1549 | nM | 9.81 |
| CHEMBL429240 | — | Ki | = | 0.2089 | nM | 9.68 |
| CHEMBL437798 | — | Ki | = | 0.3802 | nM | 9.42 |
| CHEMBL217405 | — | Ki | = | 2.188 | nM | 8.66 |
| CHEMBL274682 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL414071 | — | Ki | = | 9.333 | nM | 8.03 |