Assay Detail
Functional
CHEMBL710299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to protect the cell against HIV-2 strain ROD viral cytopathogenicity by 50% in MT-4 cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.00 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.57 |
| CHEMBL108647 | — | — | 1 | 5.40 |
| CHEMBL108396 | — | — | 1 | 4.87 |
| CHEMBL107180 | — | — | 1 | 4.79 |
| CHEMBL106661 | — | — | 1 | 4.70 |
| CHEMBL431868 | — | — | 1 | 4.66 |
| CHEMBL110625 | — | — | 1 | - |
| CHEMBL324237 | — | — | 1 | - |
| CHEMBL108605 | — | — | 1 | - |
| CHEMBL108581 | — | — | 1 | - |
| CHEMBL107606 | — | — | 1 | - |
| CHEMBL110328 | — | — | 1 | - |
| CHEMBL108360 | — | — | 1 | - |
| CHEMBL321980 | — | — | 1 | - |
| CHEMBL320056 | — | — | 1 | - |
| CHEMBL320702 | — | — | 1 | - |
| CHEMBL440706 | — | — | 1 | - |
| CHEMBL107562 | — | — | 1 | - |
| CHEMBL316773 | — | — | 1 | - |
| CHEMBL321026 | — | — | 1 | - |
| CHEMBL108196 | — | — | 1 | - |
| CHEMBL106204 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1460 | DIDANOSINE | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL108647 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL108396 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL107180 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL106661 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL431868 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL110625 | — | IC50 | >= | 275000.0 | nM | - |
| CHEMBL324237 | — | IC50 | >= | 32200.0 | nM | - |
| CHEMBL108605 | — | IC50 | >= | 293000.0 | nM | - |
| CHEMBL108581 | — | IC50 | >= | 260.0 | nM | - |
| CHEMBL107606 | — | IC50 | >= | 420.0 | nM | - |
| CHEMBL110328 | — | IC50 | >= | 196000.0 | nM | - |
| CHEMBL108360 | — | IC50 | >= | 225000.0 | nM | - |
| CHEMBL321980 | — | IC50 | > | 43100.0 | nM | - |
| CHEMBL320056 | — | IC50 | >= | 41100.0 | nM | - |
| CHEMBL320702 | — | IC50 | >= | 1250.0 | nM | - |
| CHEMBL440706 | — | IC50 | >= | 18900.0 | nM | - |
| CHEMBL107562 | — | IC50 | > | 179000.0 | nM | - |
| CHEMBL316773 | — | IC50 | > | 270000.0 | nM | - |
| CHEMBL321026 | — | IC50 | >= | 13610.0 | nM | - |
| CHEMBL108196 | — | IC50 | >= | 296000.0 | nM | - |
| CHEMBL106204 | — | IC50 | >= | 84900.0 | nM | - |