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Assay Detail

CHEMBL710708

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required to achieve 50% protection of MT-4 cells from HIV-1-induced cytopathogenicity.
ChEMBL ↗
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type MT4
Confidence 1 — Organism
Curated By Expert

Target

MT4 (CHEMBL388) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives.
Mai A, Artico M, Sbardella G, Massa S, Novellino E, Greco G, Loi AG, Tramontano E, Marongiu ME, La Colla P.
J Med Chem (1999) 42 : 619 -627
PubMed 10052969 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 51 6.28 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL35033 EMIVIRINE 2.0 1 7.52
CHEMBL87393 — — 1 7.40
CHEMBL83140 — — 1 7.30
CHEMBL157741 — — 1 7.30
CHEMBL87235 — — 1 7.30
CHEMBL87451 — — 1 7.30
CHEMBL160869 — — 1 7.10
CHEMBL309899 — — 1 7.10
CHEMBL156255 — — 1 7.10
CHEMBL312874 — — 1 7.10
CHEMBL156340 — — 1 7.05
CHEMBL156637 — — 1 7.00
CHEMBL347823 — — 1 6.85
CHEMBL154913 — — 1 6.85
CHEMBL345190 — — 1 6.75
CHEMBL157028 — — 1 6.72
CHEMBL57 NEVIRAPINE 4.0 1 6.60
CHEMBL347403 — — 1 6.60
CHEMBL155689 — — 1 6.58
CHEMBL155864 — — 1 6.57
CHEMBL351121 — — 1 6.46
CHEMBL157137 — — 1 6.40
CHEMBL155483 — — 1 6.40
CHEMBL348086 — — 1 6.39
CHEMBL156083 — — 1 6.36
CHEMBL156380 — — 1 6.35
CHEMBL112949 — — 1 6.22
CHEMBL349806 — — 1 6.22
CHEMBL109389 — — 1 6.22
CHEMBL346023 — — 1 6.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL35033 EMIVIRINE EC50 = 30.0 nM 7.52
CHEMBL87393 — EC50 = 40.0 nM 7.40
CHEMBL157741 — EC50 = 50.0 nM 7.30
CHEMBL87235 — EC50 = 50.0 nM 7.30
CHEMBL87451 — EC50 = 50.0 nM 7.30
CHEMBL83140 — EC50 = 50.0 nM 7.30
CHEMBL160869 — EC50 = 80.0 nM 7.10
CHEMBL309899 — EC50 = 80.0 nM 7.10
CHEMBL156255 — EC50 = 80.0 nM 7.10
CHEMBL312874 — EC50 = 80.0 nM 7.10
CHEMBL156340 — EC50 = 90.0 nM 7.05
CHEMBL156637 — EC50 = 100.0 nM 7.00
CHEMBL347823 — EC50 = 140.0 nM 6.85
CHEMBL154913 — EC50 = 140.0 nM 6.85
CHEMBL345190 — EC50 = 180.0 nM 6.75
CHEMBL157028 — EC50 = 190.0 nM 6.72
CHEMBL57 NEVIRAPINE EC50 = 250.0 nM 6.60
CHEMBL347403 — EC50 = 250.0 nM 6.60
CHEMBL155689 — EC50 = 260.0 nM 6.58
CHEMBL155864 — EC50 = 270.0 nM 6.57
CHEMBL351121 — EC50 = 350.0 nM 6.46
CHEMBL157137 — EC50 = 400.0 nM 6.40
CHEMBL155483 — EC50 = 400.0 nM 6.40
CHEMBL348086 — EC50 = 410.0 nM 6.39
CHEMBL156083 — EC50 = 440.0 nM 6.36
CHEMBL156380 — EC50 = 450.0 nM 6.35
CHEMBL349806 — EC50 = 600.0 nM 6.22
CHEMBL109389 — EC50 = 600.0 nM 6.22
CHEMBL112949 — EC50 = 600.0 nM 6.22
CHEMBL346023 — EC50 = 700.0 nM 6.16
CHEMBL157777 — EC50 = 810.0 nM 6.09
CHEMBL345908 — EC50 = 960.0 nM 6.02
CHEMBL157349 — EC50 = 1000.0 nM 6.00
CHEMBL156636 — EC50 = 1100.0 nM 5.96
CHEMBL351323 — EC50 = 1200.0 nM 5.92
CHEMBL160781 — EC50 = 1200.0 nM 5.92
CHEMBL111153 — EC50 = 1200.0 nM 5.92
CHEMBL345580 — EC50 = 1300.0 nM 5.89
CHEMBL322898 — EC50 = 1500.0 nM 5.82
CHEMBL114404 — EC50 = 1700.0 nM 5.77
CHEMBL157685 — EC50 = 1800.0 nM 5.75
CHEMBL156208 — EC50 = 1900.0 nM 5.72
CHEMBL422001 — EC50 = 2000.0 nM 5.70
CHEMBL323573 — EC50 = 2000.0 nM 5.70
CHEMBL156109 — EC50 = 3200.0 nM 5.50
CHEMBL345128 — EC50 = 5000.0 nM 5.30
CHEMBL415703 — EC50 = 8700.0 nM 5.06
CHEMBL347255 — EC50 = 9500.0 nM 5.02
CHEMBL316466 — EC50 = 11000.0 nM 4.96
CHEMBL347244 — EC50 = 22000.0 nM 4.66