Compound Detail
CHEMBL351323
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Basic Information
| ChEMBL ID | CHEMBL351323 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UGZFCHOGFAEXKF-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
357.3
MW (Da)
5.14
ALogP
4
HBA
1
HBD
46.0
PSA (Ų)
0.59
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.92
IC50 1 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
| MT4 CHEMBL388 | EC50 | 5.92 | 5.92 | 1200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 1100.0 | nM | 5.96 | Concentration required to inhibit the HIV-1 reverse transcriptase activity by 50... | 10052969 |
| MT4 | EC50 | = | 1200.0 | nM | 5.92 | Concentration required to achieve 50% protection of MT-4 cells from HIV-1-induce... | 10052969 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10052969 | 10.1021/jm980260f | MT4 | 3 |
| 10052969 | 10.1021/jm980260f | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine