Assay Detail
Binding
CHEMBL710993
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Binding affinity to compete for 2-[125I]iodomelatonin binding to chicken retinal membranes
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Retina |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.48 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289233 | IODOMELATONIN | — | 1 | 9.89 |
| CHEMBL421013 | — | — | 1 | 9.64 |
| CHEMBL34622 | — | — | 1 | 9.57 |
| CHEMBL34730 | — | — | 1 | 9.47 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.24 |
| CHEMBL288084 | — | — | 1 | 9.14 |
| CHEMBL99376 | — | — | 1 | 8.44 |
| CHEMBL95920 | — | — | 1 | 8.43 |
| CHEMBL99377 | — | — | 1 | 8.13 |
| CHEMBL330385 | — | — | 1 | 7.35 |
| CHEMBL53015 | — | — | 1 | 7.33 |
| CHEMBL95266 | — | — | 1 | 7.02 |
| CHEMBL316854 | — | — | 1 | 6.92 |
| CHEMBL95364 | — | — | 1 | 6.85 |
| CHEMBL421569 | — | — | 1 | 6.84 |
| CHEMBL95851 | — | — | 1 | 6.51 |
| CHEMBL52801 | — | — | 1 | 6.38 |
| CHEMBL53722 | — | — | 1 | 6.24 |
| CHEMBL322193 | — | — | 1 | 6.18 |
| CHEMBL299966 | — | — | 1 | 6.13 |
| CHEMBL50943 | — | — | 1 | 6.10 |
| CHEMBL95366 | — | — | 1 | 5.71 |
| CHEMBL99778 | — | — | 1 | 4.64 |
| CHEMBL535852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289233 | IODOMELATONIN | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL421013 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL34622 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL34730 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL45 | MELATONIN | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL288084 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL99376 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL95920 | — | Ki | = | 3.75 | nM | 8.43 |
| CHEMBL99377 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL330385 | — | Ki | = | 44.4 | nM | 7.35 |
| CHEMBL53015 | — | Ki | = | 46.3 | nM | 7.33 |
| CHEMBL95266 | — | Ki | = | 95.1 | nM | 7.02 |
| CHEMBL316854 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL95364 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL421569 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL95851 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL52801 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL53722 | — | Ki | = | 581.0 | nM | 6.24 |
| CHEMBL322193 | — | Ki | = | 665.0 | nM | 6.18 |
| CHEMBL299966 | — | Ki | = | 748.0 | nM | 6.13 |
| CHEMBL50943 | — | Ki | = | 789.0 | nM | 6.10 |
| CHEMBL95366 | — | Ki | = | 1950.0 | nM | 5.71 |
| CHEMBL99778 | — | Ki | = | 23100.0 | nM | 4.64 |
| CHEMBL535852 | — | Ki | > | 100000.0 | nM | - |