Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL711839

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]LTD4 binding on guinea-pig lung membranes
ChEMBL ↗
38
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Lung
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Cysteinyl leukotriene receptor 1 (CHEMBL5645) ↗
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Evolution of a series of non-quinoline leukotriene D4 receptor antagonist; synthesis and sar of benzothiazoles and thiazoles substituted benzyl alcohols as potent LTD4 antagonists
Lau C, Dufresne C, Gareau Y, Zamboni R, Labelle M, Young R, Metters K, Rochette C, Sawyer N, Slipetz D, Charette L, Jones T, McAuliffe M, McFarlane C, Ford-Hutchinson A
Bioorg Med Chem Lett (1995) 5 : 1615 -1620
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 8.14 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL416251 — — 2 9.30
CHEMBL287722 — — 2 9.15
CHEMBL43602 — — 2 9.10
CHEMBL42051 — — 1 9.10
CHEMBL288369 — — 1 8.82
CHEMBL295281 — — 2 8.77
CHEMBL41620 — — 1 8.72
CHEMBL416249 — — 2 8.70
CHEMBL40213 — — 1 8.68
CHEMBL43874 — — 2 8.52
CHEMBL43509 — — 1 8.48
CHEMBL280481 VERLUKAST 2.0 1 8.41
CHEMBL40992 — — 2 8.28
CHEMBL39077 — — 2 8.22
CHEMBL262391 — — 2 8.17
CHEMBL42520 — — 2 8.17
CHEMBL41395 — — 2 8.12
CHEMBL41230 — — 1 7.78
CHEMBL40686 — — 1 7.38
CHEMBL42410 — — 1 7.32
CHEMBL43821 — — 2 7.10
CHEMBL40836 — — 2 7.01
CHEMBL297396 — — 2 6.77
CHEMBL415903 — — 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL416251 — IC50 = 0.5 nM 9.30
CHEMBL416251 — IC50 = 0.6 nM 9.22
CHEMBL287722 — IC50 = 0.7 nM 9.15
CHEMBL42051 — IC50 = 0.8 nM 9.10
CHEMBL43602 — IC50 = 0.8 nM 9.10
CHEMBL287722 — IC50 = 1.0 nM 9.00
CHEMBL43602 — IC50 = 1.4 nM 8.85
CHEMBL288369 — IC50 = 1.5 nM 8.82
CHEMBL295281 — IC50 = 1.7 nM 8.77
CHEMBL41620 — IC50 = 1.9 nM 8.72
CHEMBL416249 — IC50 = 2.0 nM 8.70
CHEMBL40213 — IC50 = 2.1 nM 8.68
CHEMBL43874 — IC50 = 3.0 nM 8.52
CHEMBL43509 — IC50 = 3.3 nM 8.48
CHEMBL295281 — IC50 = 3.3 nM 8.48
CHEMBL416249 — IC50 = 3.3 nM 8.48
CHEMBL280481 VERLUKAST IC50 = 3.9 nM 8.41
CHEMBL43874 — IC50 = 4.6 nM 8.34
CHEMBL40992 — IC50 = 5.2 nM 8.28
CHEMBL39077 — IC50 = 6.0 nM 8.22
CHEMBL42520 — IC50 = 6.7 nM 8.17
CHEMBL262391 — IC50 = 6.7 nM 8.17
CHEMBL41395 — IC50 = 7.5 nM 8.12
CHEMBL39077 — IC50 = 7.7 nM 8.11
CHEMBL42520 — IC50 = 11.0 nM 7.96
CHEMBL41395 — IC50 = 11.6 nM 7.94
CHEMBL40992 — IC50 = 12.8 nM 7.89
CHEMBL262391 — IC50 = 15.4 nM 7.81
CHEMBL41230 — IC50 = 16.8 nM 7.78
CHEMBL40686 — IC50 = 42.2 nM 7.38
CHEMBL42410 — IC50 = 47.6 nM 7.32
CHEMBL43821 — IC50 = 79.3 nM 7.10
CHEMBL40836 — IC50 = 98.7 nM 7.01
CHEMBL43821 — IC50 = 99.7 nM 7.00
CHEMBL40836 — IC50 = 138.0 nM 6.86
CHEMBL297396 — IC50 = 170.0 nM 6.77
CHEMBL297396 — IC50 = 197.0 nM 6.71
CHEMBL415903 — IC50 = 381.0 nM 6.42