Assay Detail
Functional
CHEMBL712401
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Effective concentration against HIV-1 induced cytopathogenicity in MT-4 cells
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 67 | 5.50 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.00 |
| CHEMBL299714 | — | — | 1 | 6.85 |
| CHEMBL150424 | — | — | 1 | 6.85 |
| CHEMBL151896 | — | — | 1 | 6.75 |
| CHEMBL356611 | — | — | 1 | 6.66 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.52 |
| CHEMBL149275 | — | — | 1 | 6.40 |
| CHEMBL151620 | — | — | 1 | 6.00 |
| CHEMBL357327 | — | — | 1 | 6.00 |
| CHEMBL148764 | — | — | 1 | 6.00 |
| CHEMBL148987 | — | — | 1 | 6.00 |
| CHEMBL151411 | — | — | 1 | 5.77 |
| CHEMBL82415 | — | — | 1 | 5.75 |
| CHEMBL147512 | — | — | 1 | 5.70 |
| CHEMBL146981 | — | — | 1 | 5.58 |
| CHEMBL342760 | — | — | 1 | 5.30 |
| CHEMBL356875 | — | — | 1 | 5.30 |
| CHEMBL151077 | — | — | 1 | 5.01 |
| CHEMBL151664 | — | — | 1 | 5.00 |
| CHEMBL147066 | — | — | 1 | 5.00 |
| CHEMBL149104 | — | — | 1 | 4.96 |
| CHEMBL347317 | — | — | 1 | 4.92 |
| CHEMBL436263 | — | — | 1 | 4.92 |
| CHEMBL356876 | — | — | 1 | 4.89 |
| CHEMBL405364 | — | — | 1 | 4.82 |
| CHEMBL358207 | — | — | 1 | 4.82 |
| CHEMBL146957 | — | — | 1 | 4.66 |
| CHEMBL149530 | — | — | 1 | 4.57 |
| CHEMBL359093 | — | — | 1 | 4.52 |
| CHEMBL148594 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL299714 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL150424 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL151896 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL356611 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL149275 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL151620 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL357327 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL148764 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL148987 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL151411 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL82415 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL147512 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL146981 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL342760 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL356875 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL151077 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL151664 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL147066 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL149104 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL347317 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL436263 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL356876 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL358207 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL405364 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL146957 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL149530 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL359093 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL148594 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL146909 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL146954 | — | EC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL151735 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL356832 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL151566 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL359306 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL355999 | — | EC50 | > | 37000.0 | nM | - |
| CHEMBL151541 | — | EC50 | > | 75000.0 | nM | - |
| CHEMBL150871 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL82682 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL148697 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL345750 | — | EC50 | > | 12000.0 | nM | - |
| CHEMBL359155 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL423398 | — | EC50 | > | 12000.0 | nM | - |
| CHEMBL347304 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL147505 | — | EC50 | > | 4300.0 | nM | - |
| CHEMBL261989 | — | EC50 | > | 248000.0 | nM | - |
| CHEMBL148867 | — | EC50 | > | 36000.0 | nM | - |
| CHEMBL151377 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL357456 | — | EC50 | > | 238000.0 | nM | - |