Compound Detail
CHEMBL358207
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Basic Information
| ChEMBL ID | CHEMBL358207 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VFHJYKJGNBSYMB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
324.3
MW (Da)
1.81
ALogP
7
HBA
0
HBD
108.5
PSA (Ų)
0.47
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MT4 CHEMBL388 | EC50 | 4.82 | 4.82 | 15000.0 | 1 |
| Human immunodeficiency virus CHEMBL613758 | EC50 | 4.82 | 4.82 | 15080.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MT4 | EC50 | = | 15000.0 | nM | 4.82 | Effective concentration against HIV-1 induced cytopathogenicity in MT-4 cells | 8558522 |
| Human immunodeficiency virus | EC50 | = | 15080.0 | nM | 4.82 | Antiviral activity against HIV-CBL 20 infected in MT-4 cells assessed as viral r... | 30119011 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8558522 | 10.1021/jm950568w | MT4 | 3 |
| 30119011 | 10.1016/j.ejmech.2018.08.002 | Human immunodeficiency virus | 1 |
Data from ChEMBL 36 via Core Engine