Assay Detail
Binding
CHEMBL712436
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Binding affinity towards melatonin receptor using 2-[125I]iodomelatonin as radioligand in chick brain membranes
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Mapping the melatonin receptor. 1. the 5-methoxyl group of melatonin is not an essential requirement for biological activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.03 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.23 |
| CHEMBL39187 | — | — | 1 | 8.64 |
| CHEMBL43083 | — | — | 1 | 7.85 |
| CHEMBL39667 | — | — | 1 | 7.57 |
| CHEMBL14559 | — | — | 1 | 7.26 |
| CHEMBL15013 | — | — | 1 | 7.16 |
| CHEMBL40140 | — | — | 1 | 7.01 |
| CHEMBL15318 | — | — | 1 | 7.00 |
| CHEMBL15147 | — | — | 1 | 6.95 |
| CHEMBL39998 | — | — | 1 | 6.91 |
| CHEMBL289942 | — | — | 1 | 6.86 |
| CHEMBL43190 | — | — | 1 | 6.86 |
| CHEMBL278183 | — | — | 1 | 6.83 |
| CHEMBL290406 | — | — | 1 | 6.82 |
| CHEMBL274045 | — | — | 1 | 6.67 |
| CHEMBL39903 | — | — | 1 | 6.43 |
| CHEMBL42867 | — | — | 1 | 6.42 |
| CHEMBL37514 | — | — | 1 | 6.40 |
| CHEMBL33171 | NB-ACETYLTRYPTAMINE | — | 1 | 6.15 |
| CHEMBL42854 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL39187 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL43083 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL39667 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL14559 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL15013 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL40140 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL15318 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL15147 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL39998 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL289942 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL43190 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL278183 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL290406 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL274045 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL39903 | — | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL42867 | — | Ki | = | 377.0 | nM | 6.42 |
| CHEMBL37514 | — | Ki | = | 398.0 | nM | 6.40 |
| CHEMBL33171 | NB-ACETYLTRYPTAMINE | Ki | = | 701.0 | nM | 6.15 |
| CHEMBL42854 | — | Ki | = | 2600.0 | nM | 5.58 |