Assay Detail
Binding
CHEMBL712437
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Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Mapping the melatonin receptor. 3. Design and synthesis of melatonin agonists and antagonists derived from 2-phenyltryptamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.27 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417988 | — | — | 1 | 10.72 |
| CHEMBL14483 | — | — | 1 | 10.33 |
| CHEMBL14403 | — | — | 1 | 10.25 |
| CHEMBL15060 | — | — | 1 | 10.22 |
| CHEMBL14975 | — | — | 1 | 9.52 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.23 |
| CHEMBL14552 | — | — | 1 | 8.57 |
| CHEMBL15048 | — | — | 1 | 8.23 |
| CHEMBL14139 | — | — | 1 | 7.48 |
| CHEMBL14559 | — | — | 1 | 7.26 |
| CHEMBL14635 | — | — | 1 | 7.20 |
| CHEMBL15013 | — | — | 1 | 7.16 |
| CHEMBL15318 | — | — | 1 | 7.00 |
| CHEMBL15147 | — | — | 1 | 6.95 |
| CHEMBL278183 | — | — | 1 | 6.83 |
| CHEMBL279864 | — | — | 1 | 6.81 |
| CHEMBL275616 | — | — | 1 | 6.67 |
| CHEMBL274045 | — | — | 1 | 6.67 |
| CHEMBL278671 | — | — | 1 | 6.65 |
| CHEMBL15271 | — | — | 1 | 6.58 |
| CHEMBL280493 | — | — | 1 | 6.39 |
| CHEMBL14701 | — | — | 1 | 6.25 |
| CHEMBL276511 | — | — | 1 | 6.20 |
| CHEMBL14372 | — | — | 1 | 6.18 |
| CHEMBL14793 | — | — | 1 | 6.14 |
| CHEMBL14846 | — | — | 1 | 5.96 |
| CHEMBL14800 | — | — | 1 | 5.96 |
| CHEMBL278658 | — | — | 1 | 5.81 |
| CHEMBL276581 | — | — | 1 | 5.72 |
| CHEMBL15188 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417988 | — | Ki | = | 0.019 | nM | 10.72 |
| CHEMBL14483 | — | Ki | = | 0.0466 | nM | 10.33 |
| CHEMBL14403 | — | Ki | = | 0.0558 | nM | 10.25 |
| CHEMBL15060 | — | Ki | = | 0.0596 | nM | 10.22 |
| CHEMBL14975 | — | Ki | = | 0.3047 | nM | 9.52 |
| CHEMBL45 | MELATONIN | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL14552 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL15048 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL14139 | — | Ki | = | 32.8 | nM | 7.48 |
| CHEMBL14559 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL14635 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL15013 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL15318 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL15147 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL278183 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL279864 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL275616 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL274045 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL278671 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL15271 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL280493 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL14701 | — | Ki | = | 565.0 | nM | 6.25 |
| CHEMBL276511 | — | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL14372 | — | Ki | = | 659.0 | nM | 6.18 |
| CHEMBL14793 | — | Ki | = | 726.0 | nM | 6.14 |
| CHEMBL14846 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL14800 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL278658 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL276581 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL15188 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL14607 | — | Ki | = | 7000.0 | nM | 5.16 |