Assay Detail
Binding
CHEMBL712439
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Binding affinity towards melatonin receptor was determined using 2-[125I]iodomelatonin as radioligand in chick brain membranes
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Mapping the melatonin receptor. 2. synthesis and biological activity of indole derived melatonin analogues with restricted conformations of the C-3 amidoethane side chain
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.00 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290895 | — | — | 1 | 9.42 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.23 |
| CHEMBL38728 | — | — | 1 | 9.01 |
| CHEMBL441966 | — | — | 1 | 8.84 |
| CHEMBL288225 | — | — | 1 | 8.70 |
| CHEMBL38520 | — | — | 1 | 8.08 |
| CHEMBL287988 | — | — | 1 | 7.52 |
| CHEMBL287776 | — | — | 1 | 7.39 |
| CHEMBL288198 | — | — | 1 | 7.09 |
| CHEMBL417343 | — | — | 1 | 6.99 |
| CHEMBL289549 | — | — | 1 | 6.69 |
| CHEMBL287944 | — | — | 1 | 6.67 |
| CHEMBL41105 | — | — | 1 | 6.66 |
| CHEMBL290903 | — | — | 1 | 6.64 |
| CHEMBL33700 | — | — | 1 | 6.59 |
| CHEMBL38587 | — | — | 1 | 6.57 |
| CHEMBL41148 | — | — | 1 | 6.36 |
| CHEMBL290271 | — | — | 1 | 6.25 |
| CHEMBL288206 | — | — | 1 | 6.24 |
| CHEMBL291120 | — | — | 1 | 6.13 |
| CHEMBL41744 | — | — | 1 | 6.12 |
| CHEMBL38720 | — | — | 1 | 5.97 |
| CHEMBL288746 | — | — | 1 | 5.35 |
| CHEMBL289370 | — | — | 1 | 5.33 |
| CHEMBL41973 | — | — | 1 | 5.27 |
| CHEMBL41581 | — | — | 1 | - |
| CHEMBL38962 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290895 | — | Ki | = | 0.378 | nM | 9.42 |
| CHEMBL45 | MELATONIN | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL38728 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL441966 | — | Ki | = | 1.44 | nM | 8.84 |
| CHEMBL288225 | — | Ki | = | 1.98 | nM | 8.70 |
| CHEMBL38520 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL287988 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL287776 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL288198 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL417343 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL289549 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL287944 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL41105 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL290903 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL33700 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL38587 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL41148 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL290271 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL288206 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL291120 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL41744 | — | Ki | = | 766.0 | nM | 6.12 |
| CHEMBL38720 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL288746 | — | Ki | = | 4460.0 | nM | 5.35 |
| CHEMBL289370 | — | Ki | = | 4630.0 | nM | 5.33 |
| CHEMBL41973 | — | Ki | = | 5350.0 | nM | 5.27 |
| CHEMBL41581 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL38962 | — | Ki | > | 10000.0 | nM | - |