Assay Detail
Binding
CHEMBL712440
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Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of new naphthalenic derivatives as ligands for 2-[125I]iodomelatonin binding sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.98 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304203 | — | — | 1 | 10.30 |
| CHEMBL291857 | — | — | 1 | 10.15 |
| CHEMBL428882 | — | — | 1 | 10.00 |
| CHEMBL61626 | — | — | 1 | 9.40 |
| CHEMBL62992 | — | — | 1 | 9.27 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 9.27 |
| CHEMBL294517 | — | — | 1 | 9.17 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.17 |
| CHEMBL64142 | — | — | 1 | 8.86 |
| CHEMBL64471 | — | — | 1 | 8.57 |
| CHEMBL305383 | — | — | 1 | 8.10 |
| CHEMBL62574 | — | — | 1 | 7.76 |
| CHEMBL59930 | — | — | 1 | 7.71 |
| CHEMBL62306 | — | — | 1 | 7.38 |
| CHEMBL63006 | — | — | 1 | 7.16 |
| CHEMBL304685 | — | — | 1 | 6.72 |
| CHEMBL53015 | — | — | 1 | 6.69 |
| CHEMBL52801 | — | — | 1 | 6.67 |
| CHEMBL291378 | — | — | 1 | 6.66 |
| CHEMBL305075 | — | — | 1 | 6.62 |
| CHEMBL53722 | — | — | 1 | 6.60 |
| CHEMBL62495 | — | — | 1 | 6.49 |
| CHEMBL304874 | — | — | 1 | 6.41 |
| CHEMBL64699 | — | — | 1 | 6.38 |
| CHEMBL66248 | — | — | 1 | - |
| CHEMBL53721 | — | — | 1 | - |
| CHEMBL63294 | — | — | 1 | - |
| CHEMBL64651 | — | — | 1 | - |
| CHEMBL65003 | — | — | 1 | - |
| CHEMBL303598 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304203 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL291857 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL428882 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL61626 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL62992 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL10878 | AGOMELATINE | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL294517 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL45 | MELATONIN | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL64142 | — | Ki | = | 1.37 | nM | 8.86 |
| CHEMBL64471 | — | Ki | = | 2.68 | nM | 8.57 |
| CHEMBL305383 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL62574 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL59930 | — | Ki | = | 19.4 | nM | 7.71 |
| CHEMBL62306 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL63006 | — | Ki | = | 69.9 | nM | 7.16 |
| CHEMBL304685 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL53015 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL52801 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL291378 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL305075 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL53722 | — | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL62495 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL304874 | — | Ki | = | 386.0 | nM | 6.41 |
| CHEMBL64699 | — | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL66248 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL53721 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL63294 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL64651 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL65003 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL303598 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL292242 | — | Ki | > | 1000.0 | nM | - |