Assay Detail
Binding
CHEMBL712506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Pituitary gland cell |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Lutropin-choriogonadotropic hormone receptor (CHEMBL2456) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 9.18 | 9.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275935 | — | — | 1 | 9.87 |
| CHEMBL12282 | — | — | 1 | 9.32 |
| CHEMBL303274 | — | — | 1 | 8.76 |
| CHEMBL273440 | — | — | 1 | 8.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275935 | — | Kd | = | 0.1349 | nM | 9.87 |
| CHEMBL12282 | — | Kd | = | 0.4786 | nM | 9.32 |
| CHEMBL303274 | — | Kd | = | 1.738 | nM | 8.76 |
| CHEMBL273440 | — | Kd | = | 1.778 | nM | 8.75 |