Assay Detail
Binding
CHEMBL712508
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In vitro binding affinity to rat luteinizing hormone-releasing hormone (LHRH) receptor cloned in CHO cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL3066) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.83 | 9.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12282 | — | — | 1 | 9.97 |
| CHEMBL273440 | — | — | 1 | 9.63 |
| CHEMBL303274 | — | — | 1 | 9.17 |
| CHEMBL275935 | — | — | 1 | 9.16 |
| CHEMBL273275 | — | — | 1 | 8.93 |
| CHEMBL273466 | — | — | 1 | 8.67 |
| CHEMBL275467 | — | — | 1 | 8.54 |
| CHEMBL273535 | — | — | 1 | 8.54 |
| CHEMBL273387 | — | — | 1 | 8.35 |
| CHEMBL429949 | — | — | 1 | 8.28 |
| CHEMBL412634 | — | — | 1 | 8.20 |
| CHEMBL267568 | — | — | 1 | 8.10 |
| CHEMBL273536 | — | — | 1 | 8.05 |
| CHEMBL268489 | — | — | 1 | 7.85 |
| CHEMBL430312 | — | — | 1 | 7.74 |
| CHEMBL428008 | — | — | 1 | 7.30 |
| CHEMBL12666 | — | — | 1 | 6.95 |
| CHEMBL275521 | — | — | 1 | 6.92 |
| CHEMBL268491 | — | — | 1 | 6.85 |
| CHEMBL12589 | — | — | 1 | 6.66 |
| CHEMBL275251 | — | — | 1 | 6.37 |
| CHEMBL276217 | — | — | 1 | 6.16 |
| CHEMBL416337 | — | — | 1 | 5.91 |
| CHEMBL12265 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12282 | — | Ki | = | 0.1072 | nM | 9.97 |
| CHEMBL273440 | — | Ki | = | 0.2344 | nM | 9.63 |
| CHEMBL303274 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL275935 | — | Ki | = | 0.6918 | nM | 9.16 |
| CHEMBL273275 | — | Ki | = | 1.175 | nM | 8.93 |
| CHEMBL273466 | — | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL275467 | — | Ki | = | 2.884 | nM | 8.54 |
| CHEMBL273535 | — | Ki | = | 2.884 | nM | 8.54 |
| CHEMBL273387 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL429949 | — | Ki | = | 5.248 | nM | 8.28 |
| CHEMBL412634 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL267568 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL273536 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL268489 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL430312 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL428008 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL12666 | — | Ki | = | 112.2 | nM | 6.95 |
| CHEMBL275521 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL268491 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL12589 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL275251 | — | Ki | = | 426.58 | nM | 6.37 |
| CHEMBL276217 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL416337 | — | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL12265 | — | Ki | = | 2511.89 | nM | 5.60 |