Assay Detail
Binding
CHEMBL712573
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Binding affinity against human Melatonin receptor type 1A (MT1)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 10.47 | 10.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1218 | RAMELTEON | 4.0 | 1 | 10.86 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 10.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1218 | RAMELTEON | Ki | = | 0.0138 | nM | 10.86 |
| CHEMBL45 | MELATONIN | Ki | = | 0.0823 | nM | 10.08 |