Assay Detail
Binding
CHEMBL712901
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Inhibitory activity against matrix metalloprotease-9 (MMP9)
34
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.68 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 9.70 |
| CHEMBL126461 | — | — | 1 | 9.30 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.80 |
| CHEMBL126380 | — | — | 3 | 8.54 |
| CHEMBL339588 | — | — | 1 | 8.52 |
| CHEMBL126712 | — | — | 1 | 8.48 |
| CHEMBL125104 | — | — | 1 | 8.42 |
| CHEMBL127138 | — | — | 1 | 8.42 |
| CHEMBL337946 | — | — | 1 | 8.40 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.00 |
| CHEMBL126923 | — | — | 1 | 7.92 |
| CHEMBL340455 | — | — | 1 | 7.89 |
| CHEMBL339610 | — | — | 1 | 7.80 |
| CHEMBL340771 | — | — | 1 | 7.62 |
| CHEMBL339137 | — | — | 1 | 7.62 |
| CHEMBL123503 | — | — | 1 | 7.58 |
| CHEMBL338877 | — | — | 1 | 7.52 |
| CHEMBL127168 | — | — | 1 | 7.51 |
| CHEMBL126711 | — | — | 1 | 7.46 |
| CHEMBL127867 | — | — | 1 | 7.43 |
| CHEMBL127559 | — | — | 1 | 7.41 |
| CHEMBL337986 | — | — | 1 | 7.33 |
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | 7.24 |
| CHEMBL127035 | — | — | 1 | 7.21 |
| CHEMBL126977 | — | — | 1 | 7.12 |
| CHEMBL127787 | — | — | 1 | 6.88 |
| CHEMBL125901 | — | — | 1 | 6.47 |
| CHEMBL341249 | — | — | 1 | 6.29 |
| CHEMBL340345 | — | — | 1 | 6.19 |
| CHEMBL125138 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL126461 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL126380 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL339588 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL126712 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL125104 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL127138 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL337946 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL126923 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL340455 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL339610 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL339137 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL340771 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL123503 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL338877 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL127168 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL126711 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL127867 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL127559 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL126380 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL337986 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL115653 | CIPEMASTAT | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL127035 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL126977 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL126380 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL127787 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL125901 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL341249 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL340345 | — | IC50 | = | 642.0 | nM | 6.19 |
| CHEMBL125138 | — | IC50 | = | 661.0 | nM | 6.18 |
| CHEMBL339315 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL125302 | — | IC50 | > | 6.0 | nM | - |