Assay Detail
Functional
CHEMBL713410
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cells by 50%
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro -5''- (4''-amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.78 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211582 | — | — | 1 | 7.23 |
| CHEMBL2115411 | — | — | 1 | 7.22 |
| CHEMBL3142769 | — | — | 1 | 7.18 |
| CHEMBL46961 | — | — | 1 | 7.12 |
| CHEMBL3142770 | — | — | 1 | 6.91 |
| CHEMBL3142761 | — | — | 1 | 6.90 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.89 |
| CHEMBL2115239 | — | — | 1 | 6.69 |
| CHEMBL3142758 | — | — | 1 | 6.63 |
| CHEMBL3142768 | — | — | 1 | 6.42 |
| CHEMBL3142760 | — | — | 1 | 6.21 |
| CHEMBL3142762 | — | — | 1 | 6.00 |
| CHEMBL3142771 | — | — | 1 | - |
| CHEMBL3142759 | — | — | 1 | - |
| CHEMBL3142643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211582 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2115411 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3142769 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL46961 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3142770 | — | EC50 | = | 123.0 | nM | 6.91 |
| CHEMBL3142761 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL2115239 | — | EC50 | = | 206.0 | nM | 6.69 |
| CHEMBL3142758 | — | EC50 | = | 233.0 | nM | 6.63 |
| CHEMBL3142768 | — | EC50 | = | 377.0 | nM | 6.42 |
| CHEMBL3142760 | — | EC50 | = | 615.0 | nM | 6.21 |
| CHEMBL3142762 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3142771 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL3142759 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL3142643 | — | EC50 | > | 80000.0 | nM | - |