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Assay Detail

CHEMBL713546

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Functional
Compound potency to achieve protection of MT-4 cells from HIV-1 cytopathicity
ChEMBL ↗
44
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU).
Ludovici DW, Kukla MJ, Grous PG, Krishnan S, Andries K, de Béthune MP, Azijn H, Pauwels R, De Clercq E, Arnold E, Janssen PA.
Bioorg Med Chem Lett (2001) 11 : 2225 -2228
PubMed 11527703 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 6.58 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL303457 — — 2 8.60
CHEMBL305850 — — 1 8.41
CHEMBL74002 — — 1 8.30
CHEMBL308638 — — 1 8.22
CHEMBL69893 — — 1 8.15
CHEMBL302770 — — 1 7.89
CHEMBL70969 — — 1 7.85
CHEMBL71717 — — 1 7.82
CHEMBL415070 — — 1 7.58
CHEMBL440492 — — 1 7.52
CHEMBL69847 — — 1 7.17
CHEMBL70329 — — 1 7.00
CHEMBL71024 — — 1 6.91
CHEMBL72704 — — 1 6.90
CHEMBL74407 — — 1 6.83
CHEMBL71344 — — 1 6.80
CHEMBL72418 — — 1 6.80
CHEMBL70420 — — 1 6.80
CHEMBL304819 — — 1 6.67
CHEMBL69947 — — 1 6.46
CHEMBL69788 — — 1 6.42
CHEMBL72857 — — 1 6.40
CHEMBL71011 — — 1 6.28
CHEMBL312765 — — 1 6.16
CHEMBL70649 — — 1 5.88
CHEMBL304303 — — 1 5.83
CHEMBL71963 — — 1 5.79
CHEMBL71087 — — 1 5.70
CHEMBL306909 — — 1 5.29
CHEMBL74468 — — 1 5.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL303457 — IC50 = 2.5 nM 8.60
CHEMBL303457 — IC50 = 3.0 nM 8.52
CHEMBL305850 — IC50 = 3.9 nM 8.41
CHEMBL74002 — IC50 = 5.0 nM 8.30
CHEMBL308638 — IC50 = 6.0 nM 8.22
CHEMBL69893 — IC50 = 7.0 nM 8.15
CHEMBL302770 — IC50 = 13.0 nM 7.89
CHEMBL70969 — IC50 = 14.0 nM 7.85
CHEMBL71717 — IC50 = 15.0 nM 7.82
CHEMBL415070 — IC50 = 26.0 nM 7.58
CHEMBL440492 — IC50 = 30.0 nM 7.52
CHEMBL69847 — IC50 = 68.0 nM 7.17
CHEMBL70329 — IC50 = 100.0 nM 7.00
CHEMBL71024 — IC50 = 123.0 nM 6.91
CHEMBL72704 — IC50 = 126.0 nM 6.90
CHEMBL74407 — IC50 = 148.0 nM 6.83
CHEMBL70420 — IC50 = 158.0 nM 6.80
CHEMBL71344 — IC50 = 158.0 nM 6.80
CHEMBL72418 — IC50 = 160.0 nM 6.80
CHEMBL304819 — IC50 = 214.0 nM 6.67
CHEMBL69947 — IC50 = 347.0 nM 6.46
CHEMBL69788 — IC50 = 380.0 nM 6.42
CHEMBL72857 — IC50 = 400.0 nM 6.40
CHEMBL71011 — IC50 = 525.0 nM 6.28
CHEMBL312765 — IC50 = 692.0 nM 6.16
CHEMBL70649 — IC50 = 1320.0 nM 5.88
CHEMBL304303 — IC50 = 1480.0 nM 5.83
CHEMBL71963 — IC50 = 1620.0 nM 5.79
CHEMBL71087 — IC50 = 2000.0 nM 5.70
CHEMBL306909 — IC50 = 5130.0 nM 5.29
CHEMBL74468 — IC50 = 5200.0 nM 5.28
CHEMBL303377 — IC50 = 7940.0 nM 5.10
CHEMBL68099 — IC50 = 12900.0 nM 4.89
CHEMBL305778 — IC50 = 22900.0 nM 4.64
CHEMBL71101 — IC50 = 42700.0 nM 4.37
CHEMBL418880 — IC50 = 58900.0 nM 4.23
CHEMBL72170 — IC50 = 100000.0 nM 4.00
CHEMBL72822 — IC50 = 631000.0 nM -
CHEMBL70654 — IC50 > 320000.0 nM -
CHEMBL72759 — IC50 > 60000.0 nM -
CHEMBL419819 — IC50 > 160000.0 nM -
CHEMBL72825 — IC50 > 250000.0 nM -
CHEMBL72280 — IC50 = 631000.0 nM -
CHEMBL70253 — IC50 > 79000.0 nM -