Assay Detail
Binding
CHEMBL713796
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In vitro ability to inhibit the binding of [125I]AGRP to the human Melanocortin 4 receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.41 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12811 | — | — | 1 | 7.28 |
| CHEMBL441342 | — | — | 1 | 6.93 |
| CHEMBL12487 | — | — | 1 | 6.82 |
| CHEMBL12480 | — | — | 1 | 6.58 |
| CHEMBL12457 | — | — | 1 | 6.49 |
| CHEMBL275299 | — | — | 1 | 6.47 |
| CHEMBL12783 | — | — | 1 | 6.44 |
| CHEMBL12120 | — | — | 1 | 6.23 |
| CHEMBL12310 | — | — | 1 | 6.09 |
| CHEMBL12369 | — | — | 1 | 5.67 |
| CHEMBL416890 | — | — | 1 | 5.54 |
| CHEMBL12187 | — | — | 1 | - |
| CHEMBL12370 | — | — | 1 | - |
| CHEMBL12402 | — | — | 1 | - |
| CHEMBL12615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12811 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL441342 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL12487 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL12480 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL12457 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL275299 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL12783 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL12120 | — | IC50 | = | 588.0 | nM | 6.23 |
| CHEMBL12310 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL12369 | — | IC50 | = | 2146.0 | nM | 5.67 |
| CHEMBL416890 | — | IC50 | = | 2862.0 | nM | 5.54 |
| CHEMBL12187 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL12370 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL12402 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL12615 | — | IC50 | > | 10000.0 | nM | - |