Compound Detail
CHEMBL12370
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Basic Information
| ChEMBL ID | CHEMBL12370 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RKRDSFKNCKUCBZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
481.1
MW (Da)
3.69
ALogP
5
HBA
0
HBD
30.0
PSA (Ų)
0.63
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 4 CHEMBL259 | IC50 | 5.49 | 5.49 | 3226.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 4 | IC50 | = | 3226.0 | nM | 5.49 | In vitro ability to inhibit the binding of alpha [125I]NDP-MSH to the human Mela... | 12502354 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12502354 | 10.1021/jm0255522 | Melanocortin receptor 4 | 2 |
| 12502354 | 10.1021/jm0255522 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine