Assay Detail
Binding
CHEMBL713797
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In vitro ability to inhibit the binding of alpha [125I]NDP-MSH to the human Melanocortin 4 receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.35 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441342 | — | — | 1 | 6.82 |
| CHEMBL12487 | — | — | 1 | 6.79 |
| CHEMBL12480 | — | — | 1 | 6.75 |
| CHEMBL12783 | — | — | 1 | 6.73 |
| CHEMBL12457 | — | — | 1 | 6.71 |
| CHEMBL12811 | — | — | 1 | 6.66 |
| CHEMBL416890 | — | — | 1 | 6.60 |
| CHEMBL12310 | — | — | 1 | 6.33 |
| CHEMBL12369 | — | — | 1 | 6.22 |
| CHEMBL275299 | — | — | 1 | 6.22 |
| CHEMBL12120 | — | — | 1 | 5.82 |
| CHEMBL12370 | — | — | 1 | 5.49 |
| CHEMBL12615 | — | — | 1 | 5.42 |
| CHEMBL12187 | — | — | 1 | - |
| CHEMBL12402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441342 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL12487 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL12480 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL12783 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL12457 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL12811 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL416890 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL12310 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL12369 | — | IC50 | = | 597.0 | nM | 6.22 |
| CHEMBL275299 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL12120 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL12370 | — | IC50 | = | 3226.0 | nM | 5.49 |
| CHEMBL12615 | — | IC50 | = | 3829.0 | nM | 5.42 |
| CHEMBL12187 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL12402 | — | IC50 | > | 10000.0 | nM | - |