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Assay Detail

CHEMBL713936

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required to inhibit the viral (HIV-1 NNRTI resistant strain) cytopathic effect by 50% in MT-4 cells.
ChEMBL ↗
62
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.
Lagoja IM, Pannecouque C, Van Aerschot A, Witvrouw M, Debyser Z, Balzarini J, Herdewijn P, De Clercq E.
J Med Chem (2003) 46 : 1546 -1553
PubMed 12672256 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 62 5.30 6.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL273996 — — 1 6.42
CHEMBL289423 — — 1 6.01
CHEMBL38470 — — 1 5.76
CHEMBL285907 — — 1 5.73
CHEMBL37967 — — 1 5.52
CHEMBL290159 — — 1 5.40
CHEMBL289726 — — 1 5.24
CHEMBL39414 — — 1 5.01
CHEMBL287131 — — 1 4.92
CHEMBL288587 — — 1 4.65
CHEMBL289785 — — 1 4.58
CHEMBL288680 — — 1 4.38
CHEMBL279411 — — 1 -
CHEMBL38391 — — 1 -
CHEMBL38556 — — 1 -
CHEMBL39462 — — 1 -
CHEMBL288706 — — 1 -
CHEMBL38980 — — 1 -
CHEMBL38602 — — 1 -
CHEMBL289591 — — 1 -
CHEMBL39105 — — 1 -
CHEMBL37624 LOVIRIDE 2.0 1 -
CHEMBL39115 — — 1 -
CHEMBL39825 — — 1 -
CHEMBL290902 — — 1 -
CHEMBL39101 — — 1 -
CHEMBL38690 — — 1 -
CHEMBL288727 — — 1 -
CHEMBL289379 — — 1 -
CHEMBL38630 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL273996 — IC50 = 380.0 nM 6.42
CHEMBL289423 — IC50 = 970.0 nM 6.01
CHEMBL38470 — IC50 = 1730.0 nM 5.76
CHEMBL285907 — IC50 = 1860.0 nM 5.73
CHEMBL37967 — IC50 = 3000.0 nM 5.52
CHEMBL290159 — IC50 = 3990.0 nM 5.40
CHEMBL289726 — IC50 = 5770.0 nM 5.24
CHEMBL39414 — IC50 = 9720.0 nM 5.01
CHEMBL287131 — IC50 = 11890.0 nM 4.92
CHEMBL288587 — IC50 = 22570.0 nM 4.65
CHEMBL289785 — IC50 = 26100.0 nM 4.58
CHEMBL288680 — IC50 = 42180.0 nM 4.38
CHEMBL290020 — IC50 > 38690.0 nM -
CHEMBL289608 — IC50 - nM -
CHEMBL39683 — IC50 > 99400.0 nM -
CHEMBL289913 — IC50 - nM -
CHEMBL289090 — IC50 - nM -
CHEMBL290703 — IC50 > 38020.0 nM -
CHEMBL39070 — IC50 - nM -
CHEMBL288964 — IC50 > 52180.0 nM -
CHEMBL287787 — IC50 > 42630.0 nM -
CHEMBL290021 — IC50 > 40800.0 nM -
CHEMBL291259 — IC50 - nM -
CHEMBL288427 — IC50 - nM -
CHEMBL39135 — IC50 >= 53550.0 nM -
CHEMBL39815 — IC50 - nM -
CHEMBL40011 — IC50 - nM -
CHEMBL291072 — IC50 - nM -
CHEMBL290093 — IC50 > 67290.0 nM -
CHEMBL290648 — IC50 - nM -
CHEMBL289337 — IC50 - nM -
CHEMBL37624 LOVIRIDE IC50 > 10000.0 nM -
CHEMBL39101 — IC50 - nM -
CHEMBL39105 — IC50 - nM -
CHEMBL289379 — IC50 - nM -
CHEMBL288727 — IC50 - nM -
CHEMBL38690 — IC50 - nM -
CHEMBL38980 — IC50 > 36310.0 nM -
CHEMBL38630 — IC50 - nM -
CHEMBL39825 — IC50 > 38960.0 nM -
CHEMBL39115 — IC50 > 161810.0 nM -
CHEMBL290093 — IC50 - nM -
CHEMBL289591 — IC50 - nM -
CHEMBL290902 — IC50 - nM -
CHEMBL39904 — IC50 > 20440.0 nM -
CHEMBL288706 — IC50 - nM -
CHEMBL39462 — IC50 - nM -
CHEMBL38556 — IC50 - nM -
CHEMBL38391 — IC50 - nM -
CHEMBL279411 — IC50 - nM -