Assay Detail
Functional
CHEMBL713979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for maximum agonist response towards mouse melanocortin 4 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.50 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405087 | — | — | 1 | 9.70 |
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.54 |
| CHEMBL414965 | — | — | 1 | 9.42 |
| CHEMBL406842 | — | — | 1 | 9.17 |
| CHEMBL410404 | — | — | 1 | 8.85 |
| CHEMBL411378 | — | — | 1 | 8.05 |
| CHEMBL411400 | — | — | 1 | 7.70 |
| CHEMBL406891 | — | — | 1 | 7.29 |
| CHEMBL415200 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405087 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.29 | nM | 9.54 |
| CHEMBL414965 | — | EC50 | = | 0.38 | nM | 9.42 |
| CHEMBL406842 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL410404 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL411378 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL411400 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL406891 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL415200 | — | EC50 | = | 180.0 | nM | 6.75 |