Compound Detail
CHEMBL406891
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C[C@@H](O)[C@H](NC(=O)[C@H]1CCSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL406891 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | BGHGOKPNEQCGCY-RSTNRAGRSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1110.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 8.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 5 CHEMBL4489 | EC50 | 8.66 | 8.66 | 2.2 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL4077 | EC50 | 8.29 | 8.29 | 5.1 | 1 |
| Melanocortin receptor 4 CHEMBL3719 | EC50 | 7.29 | 7.29 | 51.0 | 1 |
| Melanocortin receptor 3 CHEMBL4023 | EC50 | 7.12 | 7.12 | 75.0 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL3795 | EC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 5 | EC50 | = | 2.2 | nM | 8.66 | Maximum agonist response for mouse melanocortin 5 receptor (MC5R) | 14998337 |
| Melanocyte-stimulating hormone receptor | EC50 | = | 5.1 | nM | 8.29 | Maximal agonist response of mouse melanocortin 1 receptor (MC1R) | 14998337 |
| Melanocortin receptor 4 | EC50 | = | 51.0 | nM | 7.29 | Effective concentration for maximum agonist response towards mouse melanocortin ... | 14998337 |
| Melanocortin receptor 3 | EC50 | = | 75.0 | nM | 7.12 | Maximal agonist response at rat melanocortin 3 receptor (MC3R) | 14998337 |
| Melanocyte-stimulating hormone receptor | EC50 | = | 1000.0 | nM | 6.0 | Effective concentration required for maximum agonist response at melanocortin 1 ... | 14998337 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14998337 | 10.1021/jm030452x | Melanocyte-stimulating hormone receptor | 3 |
| 14998337 | 10.1021/jm030452x | Melanocortin receptor 3 | 1 |
| 14998337 | 10.1021/jm030452x | Melanocortin receptor 4 | 1 |
| 14998337 | 10.1021/jm030452x | Melanocortin receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine