Assay Detail
Functional
CHEMBL717326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Maximal agonist response of mouse melanocortin 1 receptor (MC1R)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL4077) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.52 | 10.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 10.34 |
| CHEMBL414965 | — | — | 1 | 10.33 |
| CHEMBL405087 | — | — | 1 | 9.64 |
| CHEMBL406842 | — | — | 1 | 9.43 |
| CHEMBL410404 | — | — | 1 | 8.82 |
| CHEMBL407845 | — | — | 1 | 8.52 |
| CHEMBL406891 | — | — | 1 | 8.29 |
| CHEMBL411400 | — | — | 1 | 8.16 |
| CHEMBL405791 | — | — | 1 | 7.66 |
| CHEMBL411378 | — | — | 1 | 7.46 |
| CHEMBL415200 | — | — | 1 | 7.33 |
| CHEMBL2372365 | — | — | 1 | 6.31 |
| CHEMBL427814 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.046 | nM | 10.34 |
| CHEMBL414965 | — | EC50 | = | 0.047 | nM | 10.33 |
| CHEMBL405087 | — | EC50 | = | 0.23 | nM | 9.64 |
| CHEMBL406842 | — | EC50 | = | 0.37 | nM | 9.43 |
| CHEMBL410404 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL407845 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL406891 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL411400 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL405791 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL411378 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL415200 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2372365 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL427814 | — | EC50 | = | - | nM | - |