Compound Detail
CHEMBL411378
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Cc1nc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CSSC[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc3ccccc3)NC2=O)c[nH]1
Basic Information
| ChEMBL ID | CHEMBL411378 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | HEOQNUAQOHARQX-UCJIMMPYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1110.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 9.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 5 CHEMBL4489 | EC50 | 9.26 | 9.26 | 0.6 | 1 |
| Melanocortin receptor 4 CHEMBL3719 | EC50 | 8.05 | 8.05 | 8.9 | 1 |
| Melanocortin receptor 3 CHEMBL4023 | EC50 | 7.51 | 7.51 | 31.0 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL4077 | EC50 | 7.46 | 7.46 | 35.0 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL3795 | EC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 5 | EC50 | = | 0.55 | nM | 9.26 | Maximum agonist response for mouse melanocortin 5 receptor (MC5R) | 14998337 |
| Melanocortin receptor 4 | EC50 | = | 8.9 | nM | 8.05 | Effective concentration for maximum agonist response towards mouse melanocortin ... | 14998337 |
| Melanocortin receptor 3 | EC50 | = | 31.0 | nM | 7.51 | Maximal agonist response at rat melanocortin 3 receptor (MC3R) | 14998337 |
| Melanocyte-stimulating hormone receptor | EC50 | = | 35.0 | nM | 7.46 | Maximal agonist response of mouse melanocortin 1 receptor (MC1R) | 14998337 |
| Melanocyte-stimulating hormone receptor | EC50 | = | 10000.0 | nM | 5.0 | Effective concentration required for maximum agonist response at melanocortin 1 ... | 14998337 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14998337 | 10.1021/jm030452x | Melanocyte-stimulating hormone receptor | 3 |
| 14998337 | 10.1021/jm030452x | Melanocortin receptor 3 | 1 |
| 14998337 | 10.1021/jm030452x | Melanocortin receptor 4 | 1 |
| 14998337 | 10.1021/jm030452x | Melanocortin receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine