Assay Detail
Functional
CHEMBL714653
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Maximum agonist response for mouse melanocortin 5 receptor (MC5R)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 9.25 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 10.19 |
| CHEMBL414965 | — | — | 1 | 10.13 |
| CHEMBL405087 | — | — | 1 | 10.00 |
| CHEMBL406842 | — | — | 1 | 9.96 |
| CHEMBL410404 | — | — | 1 | 9.92 |
| CHEMBL411400 | — | — | 1 | 9.85 |
| CHEMBL411378 | — | — | 1 | 9.26 |
| CHEMBL406891 | — | — | 1 | 8.66 |
| CHEMBL405791 | — | — | 1 | 8.37 |
| CHEMBL415200 | — | — | 1 | 8.07 |
| CHEMBL2372365 | — | — | 1 | 7.34 |
| CHEMBL427814 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.064 | nM | 10.19 |
| CHEMBL414965 | — | EC50 | = | 0.074 | nM | 10.13 |
| CHEMBL405087 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL406842 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL410404 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL411400 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL411378 | — | EC50 | = | 0.55 | nM | 9.26 |
| CHEMBL406891 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL405791 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL415200 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL2372365 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL427814 | — | EC50 | = | - | nM | - |