Assay Detail
Binding
CHEMBL714106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 8.06 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287560 | — | — | 1 | 11.00 |
| CHEMBL330137 | — | — | 1 | 11.00 |
| CHEMBL314512 | — | — | 1 | 10.70 |
| CHEMBL94838 | — | — | 1 | 10.40 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.92 |
| CHEMBL323332 | — | — | 1 | 9.82 |
| CHEMBL95166 | — | — | 1 | 9.12 |
| CHEMBL96104 | — | — | 1 | 9.00 |
| CHEMBL329263 | — | — | 1 | 8.90 |
| CHEMBL96859 | — | — | 1 | 8.48 |
| CHEMBL97186 | — | — | 1 | 8.46 |
| CHEMBL94301 | — | — | 1 | 8.27 |
| CHEMBL94607 | — | — | 1 | 8.14 |
| CHEMBL315653 | — | — | 1 | 8.09 |
| CHEMBL328617 | — | — | 1 | 8.06 |
| CHEMBL96420 | — | — | 1 | 7.89 |
| CHEMBL329960 | — | — | 1 | 7.84 |
| CHEMBL329086 | — | — | 1 | 7.67 |
| CHEMBL317742 | — | — | 1 | 7.62 |
| CHEMBL94745 | — | — | 1 | 7.54 |
| CHEMBL98074 | — | — | 1 | 7.50 |
| CHEMBL33549 | — | — | 1 | 7.39 |
| CHEMBL94919 | — | — | 1 | 7.37 |
| CHEMBL96548 | — | — | 1 | 7.27 |
| CHEMBL96916 | — | — | 1 | 7.26 |
| CHEMBL96333 | — | — | 1 | 7.19 |
| CHEMBL329299 | — | — | 1 | 7.18 |
| CHEMBL314947 | — | — | 1 | 7.10 |
| CHEMBL96562 | — | — | 1 | 7.07 |
| CHEMBL440144 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287560 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL330137 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL314512 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL94838 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL45 | MELATONIN | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL323332 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL95166 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL96104 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL329263 | — | Ki | = | 1.27 | nM | 8.90 |
| CHEMBL96859 | — | Ki | = | 3.29 | nM | 8.48 |
| CHEMBL97186 | — | Ki | = | 3.51 | nM | 8.46 |
| CHEMBL94301 | — | Ki | = | 5.37 | nM | 8.27 |
| CHEMBL94607 | — | Ki | = | 7.19 | nM | 8.14 |
| CHEMBL315653 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL328617 | — | Ki | = | 8.67 | nM | 8.06 |
| CHEMBL96420 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL329960 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL329086 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL317742 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL94745 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL98074 | — | Ki | = | 31.5 | nM | 7.50 |
| CHEMBL33549 | — | Ki | = | 40.6 | nM | 7.39 |
| CHEMBL94919 | — | Ki | = | 42.7 | nM | 7.37 |
| CHEMBL96548 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL96916 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL96333 | — | Ki | = | 64.4 | nM | 7.19 |
| CHEMBL329299 | — | Ki | = | 66.4 | nM | 7.18 |
| CHEMBL314947 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL96562 | — | Ki | = | 84.5 | nM | 7.07 |
| CHEMBL440144 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL445117 | — | Ki | = | 229.0 | nM | 6.64 |
| CHEMBL96778 | — | Ki | = | 288.0 | nM | 6.54 |
| CHEMBL327864 | — | Ki | = | 476.0 | nM | 6.32 |
| CHEMBL91813 | — | Ki | = | 569.0 | nM | 6.25 |
| CHEMBL96173 | — | Ki | = | 698.0 | nM | 6.16 |