Assay Detail
Functional
CHEMBL714515
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Inhibitory activity against mast cell degranulation by measuring the content of histamine in the supernatant
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiinflammatory evaluation of 9-anilinoacridine and 9-phenoxyacridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.73 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 5.00 |
| CHEMBL142346 | — | — | 1 | 4.80 |
| CHEMBL142830 | — | — | 1 | 4.68 |
| CHEMBL140382 | — | — | 1 | 4.67 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 4.51 |
| CHEMBL359191 | — | — | 1 | - |
| CHEMBL143005 | — | — | 1 | - |
| CHEMBL141496 | — | — | 1 | - |
| CHEMBL143667 | — | — | 1 | - |
| CHEMBL51567 | — | — | 1 | - |
| CHEMBL346411 | — | — | 1 | - |
| CHEMBL141191 | — | — | 1 | - |
| CHEMBL335825 | — | — | 1 | - |
| CHEMBL143323 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL142346 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL142830 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL140382 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL359191 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL143005 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL141496 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL143667 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL51567 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL346411 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL141191 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL335825 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL143323 | — | IC50 | > | 30000.0 | nM | - |