Assay Detail
Binding
CHEMBL714671
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Concentration for half maximal activation of metabotropic glutamate mGluR4a in rat
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Metabotropic glutamate receptor 4 (CHEMBL2787) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Metabotropic glutamate receptors: novel targets for drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.47 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 2 | 6.30 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 2 | 5.50 |
| CHEMBL284377 | DEXFOSFOSERINE | 2.0 | 1 | 5.40 |
| CHEMBL34453 | — | — | 2 | 4.41 |
| CHEMBL284193 | — | — | 1 | - |
| CHEMBL279956 | QUISQUALATE | — | 2 | - |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL33567 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL284377 | DEXFOSFOSERINE | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL34453 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL34453 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL284193 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL279956 | QUISQUALATE | EC50 | > | 100000.0 | nM | - |
| CHEMBL279956 | QUISQUALATE | EC50 | = | 129000.0 | nM | - |
| CHEMBL30285 | IBOTENIC ACID | EC50 | = | 590000.0 | nM | - |