Assay Detail
Binding
CHEMBL714909
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Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Three-dimensional quantitative structure-activity relationship of melatonin receptor ligands: a comparative molecular field analysis study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 8.03 | 10.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290493 | — | — | 1 | 10.53 |
| CHEMBL289233 | IODOMELATONIN | — | 1 | 10.49 |
| CHEMBL291857 | — | — | 1 | 10.14 |
| CHEMBL322269 | — | — | 1 | 9.92 |
| CHEMBL111599 | — | — | 1 | 9.85 |
| CHEMBL37771 | — | — | 1 | 9.74 |
| CHEMBL428882 | — | — | 1 | 9.62 |
| CHEMBL61626 | — | — | 1 | 9.41 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 9.27 |
| CHEMBL62992 | — | — | 1 | 9.26 |
| CHEMBL294517 | — | — | 1 | 9.17 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.17 |
| CHEMBL124462 | — | — | 1 | 8.97 |
| CHEMBL305383 | — | — | 1 | 8.94 |
| CHEMBL64142 | — | — | 1 | 8.86 |
| CHEMBL138549 | — | — | 1 | 8.77 |
| CHEMBL37549 | — | — | 1 | 8.60 |
| CHEMBL109086 | — | — | 1 | 8.60 |
| CHEMBL64471 | — | — | 1 | 8.57 |
| CHEMBL126143 | — | — | 1 | 8.45 |
| CHEMBL428342 | — | — | 1 | 8.23 |
| CHEMBL12477 | — | — | 1 | 8.22 |
| CHEMBL137949 | — | — | 1 | 8.17 |
| CHEMBL109842 | — | — | 1 | 8.03 |
| CHEMBL349435 | — | — | 1 | 7.92 |
| CHEMBL417151 | — | — | 1 | 7.71 |
| CHEMBL342162 | — | — | 1 | 7.66 |
| CHEMBL109784 | — | — | 1 | 7.52 |
| CHEMBL12795 | — | — | 1 | 7.46 |
| CHEMBL62306 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290493 | — | Ki | = | 0.02951 | nM | 10.53 |
| CHEMBL289233 | IODOMELATONIN | Ki | = | 0.03236 | nM | 10.49 |
| CHEMBL291857 | — | Ki | = | 0.07244 | nM | 10.14 |
| CHEMBL322269 | — | Ki | = | 0.1202 | nM | 9.92 |
| CHEMBL111599 | — | Ki | = | 0.1413 | nM | 9.85 |
| CHEMBL37771 | — | Ki | = | 0.182 | nM | 9.74 |
| CHEMBL428882 | — | Ki | = | 0.2399 | nM | 9.62 |
| CHEMBL61626 | — | Ki | = | 0.389 | nM | 9.41 |
| CHEMBL10878 | AGOMELATINE | Ki | = | 0.537 | nM | 9.27 |
| CHEMBL62992 | — | Ki | = | 0.5495 | nM | 9.26 |
| CHEMBL294517 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL45 | MELATONIN | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL124462 | — | Ki | = | 1.072 | nM | 8.97 |
| CHEMBL305383 | — | Ki | = | 1.148 | nM | 8.94 |
| CHEMBL64142 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL138549 | — | Ki | = | 1.698 | nM | 8.77 |
| CHEMBL37549 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL109086 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL64471 | — | Ki | = | 2.692 | nM | 8.57 |
| CHEMBL126143 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL428342 | — | Ki | = | 5.888 | nM | 8.23 |
| CHEMBL12477 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL137949 | — | Ki | = | 6.761 | nM | 8.17 |
| CHEMBL109842 | — | Ki | = | 9.333 | nM | 8.03 |
| CHEMBL349435 | — | Ki | = | 12.02 | nM | 7.92 |
| CHEMBL417151 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL342162 | — | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL109784 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL12795 | — | Ki | = | 34.67 | nM | 7.46 |
| CHEMBL62306 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL34349 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL162456 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL162914 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL63006 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL162154 | — | Ki | = | 114.82 | nM | 6.94 |
| CHEMBL124076 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL304685 | — | Ki | = | 194.98 | nM | 6.71 |
| CHEMBL53015 | — | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL52801 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL104997 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL291378 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL165186 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL350753 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL53722 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL125081 | — | Ki | = | 288.4 | nM | 6.54 |
| CHEMBL62495 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL33171 | NB-ACETYLTRYPTAMINE | Ki | = | 489.78 | nM | 6.31 |
| CHEMBL165685 | — | Ki | = | 1905.46 | nM | 5.72 |