Assay Detail
Functional
CHEMBL714923
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Inhibitory activity against melatonin receptor of quail optica tecta with 200 pM 2-[125] iodomelatonin as gamma-S (10e-4 M)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Coturnix |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.95 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61991 | — | — | 1 | 8.52 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 7.82 |
| CHEMBL292108 | — | — | 1 | 6.40 |
| CHEMBL61418 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61991 | — | IC50 | = | 2.99 | nM | 8.52 |
| CHEMBL45 | MELATONIN | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL292108 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL61418 | — | IC50 | = | 8970.0 | nM | 5.05 |