Assay Detail
Binding
CHEMBL714926
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Binding affinity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Coturnix |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.84 | 10.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15060 | — | — | 1 | 10.77 |
| CHEMBL33415 | — | — | 1 | 10.44 |
| CHEMBL61991 | — | — | 1 | 9.41 |
| CHEMBL61380 | — | — | 1 | 9.32 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.21 |
| CHEMBL34730 | — | — | 1 | 9.00 |
| CHEMBL60832 | — | — | 1 | 8.57 |
| CHEMBL60719 | — | — | 1 | 8.10 |
| CHEMBL292108 | — | — | 1 | 7.70 |
| CHEMBL60033 | — | — | 1 | 7.20 |
| CHEMBL61418 | — | — | 1 | 6.48 |
| CHEMBL64517 | — | — | 1 | 6.44 |
| CHEMBL60001 | — | — | 1 | 6.09 |
| CHEMBL58015 | — | — | 1 | 5.92 |
| CHEMBL14701 | — | — | 1 | 5.72 |
| CHEMBL61505 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15060 | — | Ki | = | 0.017 | nM | 10.77 |
| CHEMBL33415 | — | Ki | = | 0.036 | nM | 10.44 |
| CHEMBL61991 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL61380 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL45 | MELATONIN | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL34730 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL60832 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL60719 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL292108 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL60033 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL61418 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL64517 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL60001 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL58015 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL14701 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL61505 | — | Ki | = | 9100.0 | nM | 5.04 |