Assay Detail
Binding
CHEMBL714927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Melatonin receptor using 2-[125I]iodomelatonin as radioligand
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Coturnix |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.34 | 9.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127337 | — | — | 1 | 9.75 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.21 |
| CHEMBL123900 | — | — | 1 | 8.53 |
| CHEMBL127134 | — | — | 1 | 8.24 |
| CHEMBL33700 | — | — | 1 | 8.17 |
| CHEMBL33800 | — | — | 1 | 8.05 |
| CHEMBL288562 | — | — | 1 | 7.52 |
| CHEMBL284521 | — | — | 1 | 7.14 |
| CHEMBL285477 | — | — | 1 | 6.92 |
| CHEMBL284158 | — | — | 1 | 6.75 |
| CHEMBL286814 | — | — | 1 | 6.72 |
| CHEMBL34327 | — | — | 1 | 6.54 |
| CHEMBL126809 | — | — | 1 | 6.54 |
| CHEMBL33869 | — | — | 1 | 6.42 |
| CHEMBL30930 | — | — | 1 | 6.21 |
| CHEMBL283600 | — | — | 1 | 6.19 |
| CHEMBL33099 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127337 | — | Ki | = | 0.176 | nM | 9.75 |
| CHEMBL45 | MELATONIN | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL123900 | — | Ki | = | 2.98 | nM | 8.53 |
| CHEMBL127134 | — | Ki | = | 5.75 | nM | 8.24 |
| CHEMBL33700 | — | Ki | = | 6.72 | nM | 8.17 |
| CHEMBL33800 | — | Ki | = | 8.91 | nM | 8.05 |
| CHEMBL288562 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL284521 | — | Ki | = | 72.8 | nM | 7.14 |
| CHEMBL285477 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL284158 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL286814 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL34327 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL126809 | — | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL33869 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL30930 | — | Ki | = | 617.0 | nM | 6.21 |
| CHEMBL283600 | — | Ki | = | 647.0 | nM | 6.19 |
| CHEMBL33099 | — | Ki | = | 1180.0 | nM | 5.93 |