Assay Detail
Binding
CHEMBL715495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.24 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 6.30 |
| CHEMBL34880 | — | — | 1 | 6.24 |
| CHEMBL284377 | DEXFOSFOSERINE | 2.0 | 1 | 6.00 |
| CHEMBL22136 | — | — | 1 | 5.36 |
| CHEMBL277475 | — | — | 1 | 5.33 |
| CHEMBL285043 | — | — | 1 | 5.16 |
| CHEMBL287703 | — | — | 1 | 5.10 |
| CHEMBL32142 | — | — | 1 | 5.05 |
| CHEMBL32976 | — | — | 1 | 4.57 |
| CHEMBL34453 | — | — | 1 | 4.41 |
| CHEMBL35111 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL34880 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL284377 | DEXFOSFOSERINE | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL22136 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL277475 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL285043 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL287703 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL32142 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL32976 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL34453 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL35111 | — | EC50 | = | 86000.0 | nM | 4.07 |