Compound Detail
CHEMBL32976
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Basic Information
| ChEMBL ID | CHEMBL32976 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HBLKDQXEUJOJPR-XINAWCOVSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
209.1
MW (Da)
-0.50
ALogP
3
HBA
4
HBD
120.8
PSA (Ų)
0.45
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.1
EC50 1 meas. best 4.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 4.57 | 4.57 | 27000.0 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 4.1 | 4.1 | 80000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 27000.0 | nM | 4.57 | Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian c... | 10888329 |
| Rattus norvegicus | IC50 | = | 80000.0 | nM | 4.1 | Compound was evaluated for its ability to displace [3H]APB from rat brain synapt... | 3020251 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3020251 | 10.1021/jm00160a031 | Rattus norvegicus | 5 |
| 3020251 | 10.1021/jm00160a031 | Unchecked | 2 |
| 10888329 | 10.1016/s0960-894x(00)00247-x | Metabotropic glutamate receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine