Compound Detail
CHEMBL22136
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Basic Information
| ChEMBL ID | CHEMBL22136 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TUMBRQYLINUHAB-ARJAWSKDSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
207.1
MW (Da)
-0.38
ALogP
3
HBA
4
HBD
120.8
PSA (Ų)
0.46
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 5.36 | 5.36 | 4400.0 | 1 |
| Metabotropic glutamate receptor 4 CHEMBL2787 | EC50 | 5.35 | 5.35 | 4500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 4400.0 | nM | 5.36 | Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian c... | 10888329 |
| Metabotropic glutamate receptor 4 | EC50 | = | 4500.0 | nM | 5.35 | Effective concentration against rat Metabotropic glutamate receptor 4 | 10866390 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2145435 | 10.1021/jm00172a036 | Glutamate NMDA receptor | 2 |
| 2145435 | 10.1021/jm00172a036 | Glutamate receptor ionotropic, AMPA | 1 |
| 2145435 | 10.1021/jm00172a036 | Glutamate receptor ionotropic, kainate | 1 |
| 10888329 | 10.1016/s0960-894x(00)00247-x | Metabotropic glutamate receptor 4 | 1 |
| 10866390 | 10.1016/s0960-894x(00)00197-9 | Metabotropic glutamate receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine