Assay Detail
Binding
CHEMBL715563
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Inhibition of 2-[125I]- iodomelatonin from chicken brain melatonin receptors
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Melatonergic properties of the (+)- and (-)-enantiomers of N-(4-methoxy-2,3-dihydro-1H-phenalen-2-yl)amide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.19 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428882 | — | — | 1 | 10.00 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 9.27 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.15 |
| CHEMBL276607 | — | — | 1 | 8.77 |
| CHEMBL12815 | — | — | 1 | 8.49 |
| CHEMBL273888 | — | — | 1 | 8.12 |
| CHEMBL12477 | — | — | 1 | 8.07 |
| CHEMBL12664 | — | — | 1 | 8.05 |
| CHEMBL12418 | — | — | 1 | 8.00 |
| CHEMBL12661 | — | — | 1 | 7.54 |
| CHEMBL12795 | — | — | 1 | 7.44 |
| CHEMBL12545 | — | — | 1 | 7.42 |
| CHEMBL12296 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428882 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL10878 | AGOMELATINE | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL45 | MELATONIN | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL276607 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL12815 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL273888 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL12477 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL12664 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL12418 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL12661 | — | Ki | = | 28.7 | nM | 7.54 |
| CHEMBL12795 | — | Ki | = | 36.5 | nM | 7.44 |
| CHEMBL12545 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL12296 | — | Ki | = | 787.0 | nM | 6.10 |