Assay Detail
Binding
CHEMBL715564
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Binding affinity towards melatonin receptor, determined in chicken brain membranes using [2-125I]melatonin
70
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 70 | 7.00 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53824 | — | — | 3 | 9.43 |
| CHEMBL142343 | — | — | 1 | 9.42 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.23 |
| CHEMBL127826 | — | — | 1 | 8.84 |
| CHEMBL143125 | — | — | 3 | 8.77 |
| CHEMBL359451 | — | — | 1 | 8.70 |
| CHEMBL141146 | — | — | 1 | 8.67 |
| CHEMBL342723 | — | — | 3 | 8.19 |
| CHEMBL143074 | — | — | 1 | 8.12 |
| CHEMBL38520 | — | — | 1 | 8.08 |
| CHEMBL335352 | — | — | 1 | 7.99 |
| CHEMBL142567 | — | — | 1 | 7.79 |
| CHEMBL141944 | — | — | 1 | 7.64 |
| CHEMBL139873 | — | — | 1 | 7.62 |
| CHEMBL143677 | — | — | 1 | 7.56 |
| CHEMBL424297 | — | — | 1 | 7.52 |
| CHEMBL140728 | — | — | 1 | 7.40 |
| CHEMBL127827 | — | — | 3 | 7.40 |
| CHEMBL287776 | — | — | 1 | 7.39 |
| CHEMBL143547 | — | — | 1 | 7.35 |
| CHEMBL345090 | — | — | 1 | 7.09 |
| CHEMBL435080 | — | — | 1 | 7.08 |
| CHEMBL417343 | — | — | 1 | 6.99 |
| CHEMBL143524 | — | — | 1 | 6.89 |
| CHEMBL141011 | — | — | 1 | 6.88 |
| CHEMBL344521 | — | — | 1 | 6.85 |
| CHEMBL288206 | — | — | 1 | 6.84 |
| CHEMBL343878 | — | — | 1 | 6.84 |
| CHEMBL358629 | — | — | 1 | 6.79 |
| CHEMBL348238 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53824 | — | Ki | = | 0.372 | nM | 9.43 |
| CHEMBL142343 | — | Ki | = | 0.378 | nM | 9.42 |
| CHEMBL45 | MELATONIN | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL53824 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL127826 | — | Ki | = | 1.44 | nM | 8.84 |
| CHEMBL143125 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL359451 | — | Ki | = | 1.98 | nM | 8.70 |
| CHEMBL141146 | — | Ki | = | 2.12 | nM | 8.67 |
| CHEMBL342723 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL342723 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL143074 | — | Ki | = | 7.66 | nM | 8.12 |
| CHEMBL38520 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL335352 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL143125 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL142567 | — | Ki | = | 16.1 | nM | 7.79 |
| CHEMBL141944 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL139873 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL143677 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL424297 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL127827 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL140728 | — | Ki | = | 40.2 | nM | 7.40 |
| CHEMBL287776 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL143547 | — | Ki | = | 44.7 | nM | 7.35 |
| CHEMBL53824 | — | Ki | = | 48.4 | nM | 7.32 |
| CHEMBL345090 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL435080 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL417343 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL143524 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL141011 | — | Ki | = | 131.6 | nM | 6.88 |
| CHEMBL344521 | — | Ki | = | 141.7 | nM | 6.85 |
| CHEMBL288206 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL343878 | — | Ki | = | 144.8 | nM | 6.84 |
| CHEMBL358629 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL348238 | — | Ki | = | 187.2 | nM | 6.73 |
| CHEMBL342723 | — | Ki | = | 201.5 | nM | 6.70 |
| CHEMBL127036 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL358401 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL41105 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL127827 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL142382 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL143125 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL343360 | — | Ki | = | 272.0 | nM | 6.57 |
| CHEMBL342335 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL358354 | — | Ki | = | 424.0 | nM | 6.37 |
| CHEMBL41148 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL143877 | — | Ki | = | 459.0 | nM | 6.34 |
| CHEMBL356536 | — | Ki | = | 471.0 | nM | 6.33 |
| CHEMBL140785 | — | Ki | = | 516.0 | nM | 6.29 |
| CHEMBL143543 | — | Ki | = | 555.0 | nM | 6.26 |
| CHEMBL290271 | — | Ki | = | 560.0 | nM | 6.25 |