Assay Detail
Binding
CHEMBL715567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards melatonin receptor in chicken brain.
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Mapping the melatonin receptor. 4. Comparison of the binding affinities of a series of substituted phenylalkyl amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 50 | 6.33 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34622 | — | — | 1 | 9.72 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.23 |
| CHEMBL53824 | — | — | 1 | 9.01 |
| CHEMBL53888 | — | — | 1 | 8.26 |
| CHEMBL297947 | — | — | 1 | 8.25 |
| CHEMBL54254 | — | — | 1 | 8.10 |
| CHEMBL51263 | — | — | 1 | 7.40 |
| CHEMBL53015 | — | — | 1 | 7.34 |
| CHEMBL50099 | — | — | 1 | 7.23 |
| CHEMBL53925 | — | — | 1 | 7.21 |
| CHEMBL50398 | — | — | 1 | 7.20 |
| CHEMBL299966 | — | — | 1 | 7.16 |
| CHEMBL54262 | — | — | 1 | 6.95 |
| CHEMBL50409 | — | — | 1 | 6.94 |
| CHEMBL301083 | — | — | 1 | 6.92 |
| CHEMBL53640 | — | — | 1 | 6.89 |
| CHEMBL50943 | — | — | 1 | 6.87 |
| CHEMBL53828 | — | — | 1 | 6.68 |
| CHEMBL53192 | — | — | 1 | 6.50 |
| CHEMBL54099 | — | — | 1 | 6.47 |
| CHEMBL50754 | — | — | 1 | 6.45 |
| CHEMBL301058 | — | — | 1 | 6.43 |
| CHEMBL51058 | — | — | 1 | 6.36 |
| CHEMBL50265 | — | — | 1 | 6.36 |
| CHEMBL52801 | — | — | 1 | 6.24 |
| CHEMBL54132 | — | — | 1 | 6.20 |
| CHEMBL51551 | — | — | 1 | 6.13 |
| CHEMBL51208 | — | — | 1 | 6.13 |
| CHEMBL50292 | — | — | 1 | 6.08 |
| CHEMBL54198 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34622 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL45 | MELATONIN | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL53824 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL53888 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL297947 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL54254 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL51263 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL53015 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL50099 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL53925 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL50398 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL299966 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL54262 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL50409 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL301083 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL53640 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL50943 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL53828 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL53192 | — | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL54099 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL50754 | — | Ki | = | 354.0 | nM | 6.45 |
| CHEMBL301058 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL51058 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL50265 | — | Ki | = | 434.0 | nM | 6.36 |
| CHEMBL52801 | — | Ki | = | 573.0 | nM | 6.24 |
| CHEMBL54132 | — | Ki | = | 636.0 | nM | 6.20 |
| CHEMBL51208 | — | Ki | = | 741.0 | nM | 6.13 |
| CHEMBL51551 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL50292 | — | Ki | = | 822.0 | nM | 6.08 |
| CHEMBL54198 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL53247 | — | Ki | = | 852.0 | nM | 6.07 |
| CHEMBL50311 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL299739 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL51140 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL53782 | — | Ki | = | 1920.0 | nM | 5.72 |
| CHEMBL51596 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL53783 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL50577 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL298575 | — | Ki | = | 9190.0 | nM | 5.04 |
| CHEMBL300745 | — | Ki | = | 9670.0 | nM | 5.01 |
| CHEMBL50567 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL49976 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL54144 | — | Ki | = | 15100.0 | nM | 4.82 |
| CHEMBL53502 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL299735 | — | Ki | = | 17900.0 | nM | 4.75 |
| CHEMBL53720 | — | Ki | = | 19200.0 | nM | 4.72 |
| CHEMBL301350 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL53075 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL301927 | — | Ki | = | 70800.0 | nM | 4.15 |
| CHEMBL54202 | — | Ki | > | 100000.0 | nM | - |