Assay Detail
Binding
CHEMBL715947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The development of a charged melatonin receptor ligand
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.25 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289233 | IODOMELATONIN | — | 1 | 10.10 |
| CHEMBL291857 | — | — | 1 | 10.00 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.70 |
| CHEMBL80736 | — | — | 1 | 9.41 |
| CHEMBL440692 | — | — | 1 | 8.66 |
| CHEMBL78751 | — | — | 1 | 8.37 |
| CHEMBL82135 | — | — | 1 | 8.11 |
| CHEMBL311106 | — | — | 1 | 8.09 |
| CHEMBL80792 | — | — | 1 | 7.38 |
| CHEMBL78338 | — | — | 1 | 7.03 |
| CHEMBL79224 | — | — | 1 | 7.00 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.15 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289233 | IODOMELATONIN | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL291857 | — | Ki | = | 0.099 | nM | 10.00 |
| CHEMBL45 | MELATONIN | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL80736 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL440692 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL78751 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL82135 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL311106 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL80792 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL78338 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL79224 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL59 | DOPAMINE | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL39 | SEROTONIN | Ki | > | 100000.0 | nM | - |