Assay Detail
Binding
CHEMBL715955
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Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.25 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.54 |
| CHEMBL99502 | — | — | 1 | 7.30 |
| CHEMBL100104 | — | — | 1 | 7.20 |
| CHEMBL329979 | — | — | 1 | 7.06 |
| CHEMBL99084 | — | — | 1 | 6.87 |
| CHEMBL287343 | — | — | 1 | 6.65 |
| CHEMBL98028 | — | — | 1 | 6.62 |
| CHEMBL98956 | — | — | 1 | 6.56 |
| CHEMBL99001 | — | — | 1 | 6.51 |
| CHEMBL318871 | — | — | 1 | 6.48 |
| CHEMBL34728 | — | — | 1 | 6.39 |
| CHEMBL34729 | — | — | 1 | 6.28 |
| CHEMBL418789 | — | — | 1 | 6.20 |
| CHEMBL33346 | — | — | 1 | 6.20 |
| CHEMBL99987 | — | — | 1 | 6.16 |
| CHEMBL99002 | — | — | 1 | 6.08 |
| CHEMBL99534 | — | — | 1 | 5.91 |
| CHEMBL33185 | — | — | 1 | 5.89 |
| CHEMBL97885 | — | — | 1 | 5.89 |
| CHEMBL98484 | — | — | 1 | 5.74 |
| CHEMBL99083 | — | — | 1 | 5.61 |
| CHEMBL99000 | — | — | 1 | 5.53 |
| CHEMBL98520 | — | — | 1 | 5.50 |
| CHEMBL316952 | — | — | 1 | 5.42 |
| CHEMBL99512 | — | — | 1 | 5.40 |
| CHEMBL99091 | — | — | 1 | 5.07 |
| CHEMBL319970 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.2884 | nM | 9.54 |
| CHEMBL99502 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL100104 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL329979 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL99084 | — | Ki | = | 134.9 | nM | 6.87 |
| CHEMBL287343 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL98028 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL98956 | — | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL99001 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL318871 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL34728 | — | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL34729 | — | Ki | = | 524.81 | nM | 6.28 |
| CHEMBL418789 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL33346 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL99987 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL99002 | — | Ki | = | 831.76 | nM | 6.08 |
| CHEMBL99534 | — | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL33185 | — | Ki | = | 1288.25 | nM | 5.89 |
| CHEMBL97885 | — | Ki | = | 1288.25 | nM | 5.89 |
| CHEMBL98484 | — | Ki | = | 1819.7 | nM | 5.74 |
| CHEMBL99083 | — | Ki | = | 2454.71 | nM | 5.61 |
| CHEMBL99000 | — | Ki | = | 2951.21 | nM | 5.53 |
| CHEMBL98520 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL316952 | — | Ki | = | 3801.89 | nM | 5.42 |
| CHEMBL99512 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL99091 | — | Ki | = | 8511.38 | nM | 5.07 |
| CHEMBL319970 | — | Ki | = | 16218.1 | nM | 4.79 |