Assay Detail
Binding
CHEMBL716133
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Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 1 (CHEMBL4477) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.60 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43412 | — | — | 1 | 4.60 |
| CHEMBL8759 | EGLUMETAD | 2.0 | 1 | - |
| CHEMBL39215 | — | — | 1 | - |
| CHEMBL39185 | — | — | 1 | - |
| CHEMBL288635 | — | — | 1 | - |
| CHEMBL284193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43412 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL8759 | EGLUMETAD | IC50 | = | 458000.0 | nM | - |
| CHEMBL39215 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL39185 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL288635 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL284193 | — | IC50 | = | 389000.0 | nM | - |