Assay Detail
Functional
CHEMBL718087
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Agonistic activity measured as inhibition of cAMP accumulation in HEK cells expressing human Melanocortin 4 receptor (hMC4R)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aryl piperazine melanocortin MC4 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.33 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339053 | — | — | 1 | 8.40 |
| CHEMBL333283 | — | — | 1 | 7.62 |
| CHEMBL340355 | — | — | 1 | 7.10 |
| CHEMBL123426 | — | — | 1 | 6.96 |
| CHEMBL435410 | — | — | 1 | 6.77 |
| CHEMBL338768 | — | — | 1 | 6.72 |
| CHEMBL338594 | — | — | 1 | 6.42 |
| CHEMBL339545 | — | — | 1 | 6.42 |
| CHEMBL338274 | — | — | 1 | 6.36 |
| CHEMBL124688 | — | — | 1 | 6.33 |
| CHEMBL338277 | — | — | 1 | 6.28 |
| CHEMBL125935 | — | — | 1 | 6.22 |
| CHEMBL127491 | — | — | 1 | 6.19 |
| CHEMBL124633 | — | — | 1 | 6.17 |
| CHEMBL338275 | — | — | 1 | 6.16 |
| CHEMBL337941 | — | — | 1 | 6.00 |
| CHEMBL340908 | — | — | 1 | 6.00 |
| CHEMBL333368 | — | — | 1 | 5.96 |
| CHEMBL127461 | — | — | 1 | 5.80 |
| CHEMBL127574 | — | — | 1 | 5.72 |
| CHEMBL333071 | — | — | 1 | 5.68 |
| CHEMBL339708 | — | — | 1 | 5.66 |
| CHEMBL339979 | — | — | 1 | 5.62 |
| CHEMBL125529 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339053 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL333283 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL340355 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL123426 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL435410 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL338768 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL338594 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL339545 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL338274 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL124688 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL338277 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL125935 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL127491 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL124633 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL338275 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL337941 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL340908 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL333368 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL127461 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL127574 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL333071 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL339708 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL339979 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL125529 | — | EC50 | = | 4400.0 | nM | 5.36 |